Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4756930..4757291 Replicon chromosome
Accession NZ_CP060470
Organism Xanthomonas citri pv. citri strain DAR73889

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag H8Z72_RS20590 Protein ID WP_005914328.1
Coordinates 4756930..4757064 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag H8Z72_RS20595 Protein ID WP_003486606.1
Coordinates 4757139..4757291 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z72_RS20570 4752073..4753759 - 1687 Protein_4023 M20/M25/M40 family metallo-hydrolase -
H8Z72_RS20575 4753951..4754985 - 1035 WP_011052671.1 MBL fold metallo-hydrolase -
H8Z72_RS20580 4755024..4756313 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
H8Z72_RS20585 4756494..4756703 - 210 WP_003486601.1 CsbD family protein -
H8Z72_RS20590 4756930..4757064 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
H8Z72_RS20595 4757139..4757291 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
H8Z72_RS20600 4757398..4758321 - 924 WP_005927745.1 arginase -
H8Z72_RS20605 4758642..4759094 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
H8Z72_RS20610 4759158..4759517 + 360 WP_003486613.1 hypothetical protein -
H8Z72_RS20615 4759614..4760531 + 918 WP_040280500.1 hypothetical protein -
H8Z72_RS20620 4760528..4761070 + 543 WP_003486615.1 GTPase -
H8Z72_RS20625 4761508..4762191 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T170450 WP_005914328.1 NZ_CP060470:c4757064-4756930 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T170450 NZ_CP077388:2031826-2032029 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTGAGAAAATGCACAACAATTGAAACACTTGAGCGTGTCATTGAAAAAAACAA
GTATGAACTATCTGATGATGAACTAGAGTTATTCTACTCAGCGGCAGATCATCGTCTTGCTGAACTCACTATGAATAAGC
TCTACGATAAAATTCCACCTTCTGTATGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT170450 WP_003486606.1 NZ_CP060470:c4757291-4757139 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT170450 NZ_CP077388:2031383-2031751 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAACAGTCTCAATAGAGACGCTATCTT
AAGTTTGCAAAAAACCAACACACATTGGATTAACGATCTAAGCTCTGCACAAAGTGCAGCTCTAAATGAACTCATTGAAC
ATATCGCAGCTTTTGTCTGGCGATTTAAGATCAAATATCCAAAAGAAAATCTCGTTATATCATTAATTGAAGAGTACCTC
GATGAGACTTATGACTTATTTGGTAGCCCAGTCATCACATTAAGTGAAATTATAGATTGGGAAACTATGAATCAAAATCT
AGTTTCAGTGCTGGATGATGACCTAAAATGTCTGACCAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References