Detailed information of TA system TA170446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 21912..22449
• Replicon: plasmid pXAS28
• Accession: NZ_CP060468
• Organism: Xanthomonas citri pv. citri strain DAR73886

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H8Z71_RS23085
• Protein ID: WP_040245198.1
• Coordinates: 21912..22193 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X9UWY6
• Locus tag: H8Z71_RS23090
• Protein ID: WP_017158384.1
• Coordinates: 22180..22449 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8Z71_RS23055	17689..19263	-	1575	WP_045123781.1	type IV secretion system DNA-binding domain-containing protein	-
H8Z71_RS23060	19267..19440	-	174	WP_162886871.1	hypothetical protein	-
H8Z71_RS23065	19440..19835	-	396	WP_039447651.1	hypothetical protein	-
H8Z71_RS23070	20225..20671	+	447	WP_033483209.1	hypothetical protein	-
H8Z71_RS23075	20668..21375	+	708	WP_045123792.1	hypothetical protein	-
H8Z71_RS23080	21421..21774	+	354	WP_033481414.1	hypothetical protein	-
H8Z71_RS23085	21912..22193	-	282	WP_040245198.1	type II toxin-antitoxin system YafQ family toxin	Toxin
H8Z71_RS23090	22180..22449	-	270	WP_017158384.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H8Z71_RS23095	22558..23526	-	969	WP_040245200.1	recombinase family protein	-
H8Z71_RS23100	24078..24359	-	282	WP_017161425.1	hypothetical protein	-
H8Z71_RS23105	24383..25081	-	699	WP_078538983.1	AAA family ATPase	-
H8Z71_RS23110	25767..26588	-	822	WP_033838015.1	hypothetical protein	-
H8Z71_RS23115	27098..27427	-	330	WP_017159849.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..28110	28110

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-86)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10693.08 Da
• Isoelectric Point: 8.9188

>T170446 WP_040245198.1 NZ_CP060468:c22193-21912 [Xanthomonas citri pv. citri]
MRTIDRSSAFKRDYKREAKGQHRATLDDAIKPVLVALATDQPPDARYRDHDLSGDWAGYRECHIKPDLLLIYRKSDPETL
RLARLGSHSELFG

Nucleotide

• Length: 282 bp

>T170446 NZ_CP077378:c56611-55301 [Aeromonas sp. FDAARGOS 1406]
ATGGCCAGCCTGACGGTCTACATGAACGGATACCGGGTAGGTACCTTTACCAAGGCGACCAATGGTGCTCACCAATTTCA
GTACGATGAATCGTGGGTGAAGTTGCCAGGCAGCCGCCCCATCTCGCTCTCCATGCCATTACGCCAGCAGCGCTACCAGG
GCGATGAGGCCTATAACTTCTTCGATAATCTGCTGCCAGATAACCCGGAAGTAAGAAACCGGGTGGTGGCGCGCTATCAA
GCCGATTCCACCCAACCCTTTGATCTGCTCAGTTGCATTGGCCAGGACAGCGTGGGGGCATTGCAACTGGTGGCTCAGGG
CAGACCTGTGCCAGACGTTAAGCGCATTGAGTGCAAGCCGCTCTCTGACGCCGAACTGGAGCAGATCCTGACCAGCTACC
AGCAAGGGATCCCGCTTGGTATGGTGAGGGAAGAGGACGATTTTCGGATATCCATCGCCGGGGCTCAGGAAAAGACCGCG
TTACTCTACCTCGACAACCGTTGGTGCTTACCGCATGCAGCGACCCCAACCACCCACATTATCAAGCTGCCCATTGGCAA
GATCGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACCCTGATCGCCAAAGCAT
TGGGTCTTCCGGTTCCCCATTGCTTCATCATGCAGGTCGGCAAGGTCAAGGCTCTGGCGGTGGAACGCTTCGATCGGCGC
TACGCCACGGATCGCAGTTGGATCATGCGCCTGCCCCAAGAGGACTTCTGCCAGGTGTTGAATGTACCGTCAGCACGCAA
GTACGAGAGCCATGGTGGACCGGGCATTGCTGACATCATGACGACCCTGCTGGGATCGGCCACGCCGGAGCAGGATCGGT
ACCTGTTTATGAAGTCTCAGGTGTTGTTCTGGCTGCTGGCTGCCACTGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCTGAAGGGCGTTTCCGGCTTACACCGTTTTACGACATCCTTTCCATGTATCCTGCATTTGGTGGTAAAGGATTACA
TCCCCGTGATGCCAAGTTGGCCATGGGGCTTACTGCAACCAAGGGCAAAAAATACGCGATAGAGCAGATATTTCCTCGCC
ATTTTTATCAAACGGCCAAGGCGATTGGTTTTGAACAAGTGCAGATGGAAAAAATCATCAGCGAGCTGACGGATAATCTG
GATGAGGTAATATCAATCGTTCGTCAGCAATTGCCTGATACATTTCCCACTGAGATTACAGATTCAATTTTGGGTGGACT
CAGTTCGAGAGCTCAACGCTTAAAACGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9719.10 Da
• Isoelectric Point: 5.6976

>AT170446 WP_017158384.1 NZ_CP060468:c22449-22180 [Xanthomonas citri pv. citri]
MSTTADTYVRARIDTATKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNTTTKKAIAELESGKGKKFANVDD
LMADLHADD

Nucleotide

• Length: 270 bp

>AT170446 NZ_CP077378:c56865-56611 [Aeromonas sp. FDAARGOS 1406]
ATGAAAGTAACCAGCGCCAAGCAACTTAGTGCCTGTCTCAAGGATGCCAGGCTTTCGCAAAAGCTCTCCCAAGGCAAAGT
GGCCGGCAAGGTGGGGATCAGGCAGGACACGGTGTCCAGCTTCGAGCTCAATCCCGAGTCAACCAAGCTGGAGACCTTGT
TCAAGATCCTCGCCGCACTGGAACTCTCCCTCGATATCAGGCCCCGCACCGATCCTGCGGAAAACGCCACGCCTGGCTGG
AAGGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7X9UWY6