Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5131894..5132561 Replicon chromosome
Accession NZ_CP060465
Organism Xanthomonas citri pv. citri strain DAR73886

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag H8Z71_RS22015 Protein ID WP_005916679.1
Coordinates 5132145..5132561 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag H8Z71_RS22010 Protein ID WP_005916676.1
Coordinates 5131894..5132148 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z71_RS21985 5128004..5128223 + 220 Protein_4297 RNA 2'-phosphotransferase -
H8Z71_RS21990 5128392..5129657 + 1266 WP_015463799.1 cardiolipin synthase B -
H8Z71_RS21995 5129683..5130210 - 528 WP_005916668.1 hypothetical protein -
H8Z71_RS22000 5130449..5130655 + 207 WP_003489327.1 hypothetical protein -
H8Z71_RS22005 5130642..5131748 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8Z71_RS22010 5131894..5132148 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
H8Z71_RS22015 5132145..5132561 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
H8Z71_RS22020 5132683..5132955 - 273 WP_125459513.1 hypothetical protein -
H8Z71_RS22025 5133014..5133226 - 213 WP_015472901.1 hypothetical protein -
H8Z71_RS22030 5133483..5135102 + 1620 WP_015463800.1 hypothetical protein -
H8Z71_RS22035 5135206..5135604 - 399 WP_004429277.1 DUF2384 domain-containing protein -
H8Z71_RS22040 5135920..5136351 + 432 WP_005922907.1 hypothetical protein -
H8Z71_RS22045 5136380..5136706 - 327 Protein_4309 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T170442 WP_005916679.1 NZ_CP060465:5132145-5132561 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T170442 NZ_CP077374:c5886-5599 [Acinetobacter lwoffii]
ATGGAACAATATTTCGAATGGGATGAGGCAAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTCTTTGATGATCCATTAAGGATATCAATCCAGGACAGACATACTGATGGTGAAGAACGTTGGCAAACCATTGGAA
GAGTAAAAGGCGTACTAATGCTATTAGTAGCTCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTCACTAAGGCGGAGCGCGATAAATATGAGCACGGTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT170442 WP_005916676.1 NZ_CP060465:5131894-5132148 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT170442 NZ_CP077374:c5612-5298 [Acinetobacter lwoffii]
ATGAGCACGGTTAGATACTCACGCAAAGAACTAAATGAAAAATTTAGTGAGAAGCAAGATGCTGAAATCGAACGCTTGCT
TACGAAGGGGACGGTTCCTGATGATCAGCTAGATTTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
ATAATCAATTCTATCGCCCAGTGAAGCAACAGACCTCCATTCGTTTAGATGCTGATGTACTTGCATGGTTTAAAGCTCAA
GGTAAAGGCTATCAAACCCGGATGAATGAGATTCTGCGAGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References