Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5146601..5147268 Replicon chromosome
Accession NZ_CP060460
Organism Xanthomonas citri pv. citri strain DAR84832

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag H8Z70_RS22130 Protein ID WP_005916679.1
Coordinates 5146852..5147268 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag H8Z70_RS22125 Protein ID WP_005916676.1
Coordinates 5146601..5146855 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z70_RS22100 5142711..5142930 + 220 Protein_4320 RNA 2'-phosphotransferase -
H8Z70_RS22105 5143099..5144364 + 1266 WP_015463799.1 cardiolipin synthase B -
H8Z70_RS22110 5144390..5144917 - 528 WP_005916668.1 hypothetical protein -
H8Z70_RS22115 5145156..5145362 + 207 WP_003489327.1 hypothetical protein -
H8Z70_RS22120 5145349..5146455 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8Z70_RS22125 5146601..5146855 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
H8Z70_RS22130 5146852..5147268 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
H8Z70_RS22135 5147390..5147602 - 213 WP_015472900.1 hypothetical protein -
H8Z70_RS22140 5147721..5147933 - 213 WP_015472901.1 hypothetical protein -
H8Z70_RS22145 5148190..5149809 + 1620 WP_015463800.1 hypothetical protein -
H8Z70_RS22150 5149913..5150311 - 399 WP_004429277.1 DUF2384 domain-containing protein -
H8Z70_RS22155 5150627..5151058 + 432 WP_005922907.1 hypothetical protein -
H8Z70_RS22160 5151087..5151413 - 327 Protein_4332 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T170435 WP_005916679.1 NZ_CP060460:5146852-5147268 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T170435 NZ_CP077368:c382126-381815 [Pantoea agglomerans]
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCCTCCGCACTGGATGCGGCTTA
TCTGGTCCTAAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTCGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGAATCATGTTTTATGCTGACTTTGATCGCGGCAAAATT
TTTATCAAACACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT170435 WP_005916676.1 NZ_CP060460:5146601-5146855 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT170435 NZ_CP077368:c381818-381405 [Pantoea agglomerans]
ATGATTACCGAAGCAATCCAGGCGACCAATGACCTGGTCAGAATTGTTCCCTTTCTGGGAGGCAGTACCGATAAAAGGGA
CTACGAGCAGGCGCTGGAACTGGTTGAATATCTGGTTGAGCACCAGCCGGACAGCCCGTTAGTAGAGATACTGTCTGATA
AAGTCGCCCGATACGAAAACAGCGCCCCTGAGTTCGCTGCGTTTAACGCGCGTACTGATGCTATTCCGCGCGGAGTAGCA
CTTTTGCGAGTCATCATGGATCAGCACGGCCTGACTCAATCCTCTTTTGCGGATGAAATAGGGCAGCGCTCTTATGTCAG
TCGTATCCTGCGTGGTGATCGTCCTTTGACGGATAAACATAAAGCCCGACTGGCAGCGCGTTTTAACCTGCCGTTTGAAG
CATTCGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References