Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5110295..5110962 Replicon chromosome
Accession NZ_CP060453
Organism Xanthomonas citri pv. citri strain DAR73909

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag H8Z74_RS21825 Protein ID WP_005916679.1
Coordinates 5110546..5110962 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag H8Z74_RS21820 Protein ID WP_005916676.1
Coordinates 5110295..5110549 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z74_RS21795 5106405..5106624 + 220 Protein_4259 RNA 2'-phosphotransferase -
H8Z74_RS21800 5106793..5108058 + 1266 WP_040280600.1 cardiolipin synthase B -
H8Z74_RS21805 5108108..5108611 - 504 Protein_4261 hypothetical protein -
H8Z74_RS21810 5108850..5109056 + 207 WP_003489327.1 hypothetical protein -
H8Z74_RS21815 5109043..5110149 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8Z74_RS21820 5110295..5110549 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
H8Z74_RS21825 5110546..5110962 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
H8Z74_RS21830 5111084..5111296 - 213 WP_015472900.1 hypothetical protein -
H8Z74_RS21835 5111415..5111627 - 213 WP_015472901.1 hypothetical protein -
H8Z74_RS21840 5111884..5113503 + 1620 WP_015463800.1 hypothetical protein -
H8Z74_RS21845 5113607..5114005 - 399 WP_004429277.1 DUF2384 domain-containing protein -
H8Z74_RS21850 5114321..5114752 + 432 WP_005922907.1 hypothetical protein -
H8Z74_RS21855 5114781..5115107 - 327 Protein_4271 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T170428 WP_005916679.1 NZ_CP060453:5110546-5110962 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T170428 NZ_CP077366:3580715-3580930 [Pantoea agglomerans]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGCTGCCGCTCTCTTGATACCCTGGAAAGGGTGAT
TGAAAAAAATAAGTATGAATTACCGGAAGATGAATTAGCGGTATTTTACTCAGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCGGGTTCAGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT170428 WP_005916676.1 NZ_CP060453:5110295-5110549 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT170428 NZ_CP077366:3580313-3580690 [Pantoea agglomerans]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTTTGTGAGAGTCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCATGGCTGGGTTAATGATCCCACTTCTGAAAGCAATCTACAGCTTAACGATTTGATTGAGC
ATATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAATTATGGTGTCAATAGTCCGGATCTTCAGCGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References