Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4711191..4711552 Replicon chromosome
Accession NZ_CP060453
Organism Xanthomonas citri pv. citri strain DAR73909

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag H8Z74_RS20240 Protein ID WP_005914328.1
Coordinates 4711191..4711325 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag H8Z74_RS20245 Protein ID WP_003486606.1
Coordinates 4711400..4711552 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z74_RS20220 4706334..4708020 - 1687 Protein_3953 M20/M25/M40 family metallo-hydrolase -
H8Z74_RS20225 4708212..4709246 - 1035 WP_011052671.1 MBL fold metallo-hydrolase -
H8Z74_RS20230 4709285..4710574 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
H8Z74_RS20235 4710755..4710964 - 210 WP_003486601.1 CsbD family protein -
H8Z74_RS20240 4711191..4711325 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
H8Z74_RS20245 4711400..4711552 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
H8Z74_RS20250 4711659..4712582 - 924 WP_005927745.1 arginase -
H8Z74_RS20255 4712903..4713355 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
H8Z74_RS20260 4713419..4713778 + 360 WP_003486613.1 hypothetical protein -
H8Z74_RS20265 4713875..4714792 + 918 WP_011052673.1 hypothetical protein -
H8Z74_RS20270 4714789..4715331 + 543 WP_003486615.1 GTPase -
H8Z74_RS20275 4715769..4716452 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T170427 WP_005914328.1 NZ_CP060453:c4711325-4711191 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T170427 NZ_CP077366:2874463-2874798 [Pantoea agglomerans]
ATGGTAAGCCGTTTTGTCCCTGATGCGGGAGATATCATCTGGGTGGATTTTGATCCGACCAAAGGCAGTGAGCAGGCAGG
TCACAGACCCGCTATTGTTCTTAGCCCGTTTGCTTACAATGACAAGACCGGCATGTGTCTCTGTGTCCCCTGCACCACCC
TGTCAAAGGGGTATCCGTTTGAAGTCCCCATAAGTGCTGAAAAAGAAAGCGTCGCCTTATCCGATCAAGTGAAAAGCATC
GCCTGGAAAGTCAGGGGAGCAACCAAAAAAGGCGTTGTTTCCGCAAACGAACTTCAGCAAATTCGCGCTAAGATAAAAGT
TATCATTGGCTTATAG

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT170427 WP_003486606.1 NZ_CP060453:c4711552-4711400 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT170427 NZ_CP077366:2874214-2874462 [Pantoea agglomerans]
ATGATTCATGGAAAGGTTAAACGCTGGGGTAACTCTCCGGCGATACGTATCCCGGCGACATTGATGCAGGCACTAAATCT
TAATATTGATGACGAAATTAAAATCGATTTAGTTGAAGGGAAACTCATTATCGAGCCTGTCAAACAGGAAGTGGGTTACT
CTCTTGAAGAACTGCTTGAAGGCGTGACAGAGGAAAATCTGCACGATCCAGTCGAATGGGGTGAACCTGTCGGGAAGGAG
ATTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References