Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 2658582..2659215 Replicon chromosome
Accession NZ_CP060453
Organism Xanthomonas citri pv. citri strain DAR73909

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8Z74_RS11585 Protein ID WP_015463212.1
Coordinates 2658582..2658995 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4TWF0
Locus tag H8Z74_RS11590 Protein ID WP_015463213.1
Coordinates 2658982..2659215 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z74_RS11565 2655403..2656029 + 627 WP_040152219.1 conjugal transfer protein TraG N-terminal domain-containing protein -
H8Z74_RS11570 2656090..2657257 + 1168 Protein_2254 IS3 family transposase -
H8Z74_RS11575 2657254..2658177 + 924 WP_203179210.1 conjugal transfer protein TraG N-terminal domain-containing protein -
H8Z74_RS11580 2658193..2658555 - 363 WP_015463211.1 DUF3742 family protein -
H8Z74_RS11585 2658582..2658995 - 414 WP_015463212.1 PIN domain-containing protein Toxin
H8Z74_RS11590 2658982..2659215 - 234 WP_015463213.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H8Z74_RS11595 2659473..2660504 + 1032 WP_040107627.1 DUF4917 family protein -
H8Z74_RS11600 2660637..2661035 - 399 WP_099521978.1 hypothetical protein -
H8Z74_RS11605 2661487..2662062 + 576 WP_011051400.1 sigma-70 family RNA polymerase sigma factor -
H8Z74_RS11610 2662043..2663092 + 1050 WP_015472205.1 FecR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-119)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15221.65 Da        Isoelectric Point: 6.3225

>T170425 WP_015463212.1 NZ_CP060453:c2658995-2658582 [Xanthomonas citri pv. citri]
MAAGKGKVFLDSNVVLYLLSEDAVKADGAEALLQRRPVISVQVLNEVTHVCVRKLKMGWDEVGQFLALVRSFCKIVPLTV
DVHDRARQLAERHQLSFYDACIVAAAAIEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Download         Length: 414 bp

>T170425 NZ_CP077366:2609409-2610722 [Pantoea agglomerans]
ATGCAAAGGTTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTACTCACCCGCCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGGCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTTTCGATGCCGTTGCAGGTTAAGGCTCTCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCGGATAGCCCATTGATTCGCGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCCTTTGATCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACTATGCTGCTGCCGCCCGA
TATGCCACTGCCCGCACTGCAGGCCCGCTATGAAGTGCTGGATGAAACCCGGCTCGAAAGCGTGCTGTCGGCCTATCAGT
CAGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGATTTCCGTATCTCGGTCGCAGGGGCGCAGGAGAAAACCGCACTG
CTGCTGACCGATGAAGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGAGAGAT
TAAACAGCCGGCCGCGACGCTGGATATGCGTGAAAGTGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGTGCACTCG
GTATCGACGTGCCGCAGGCAACGATTATCCGTGCCGGACAGATGCGCGCCCTGGCGGTAGAACGTTTCGACCGCCGCTGG
TCACGCGATAAAACCCGGTTGATTCGCCTGCCGCAGGAGGATTTCTGTCAGGCGCTGGGACTGCCATCTTCAACCAAATA
TGAGTCGGATGGCGGGCCAGGCATTGCGGAGATCATGCAGATACTGATGGGATCGAGCAACGCCATCGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGCGCAACCGACGGTCACGCCAAGAACTTCTCACTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACTCCCTTTTATGATGTGATCTCCGCTTACCCGGTACTGGGCGGCACCGGTCTGAACAA
GCGAGCGCTGAAACTGGCGATGGGTCTGCGTGCCACTAAGGGGAAGAAGACAGAGATCGACAAAATCTTCCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTTATTAAGGCCTTTCCC
CAGGCAGTGGTCTCGGTGCGCGATGCCTTGCCGCCCGATTTCCCGCAGCACATCGCCGACGCCATCTTCAGTCATTCACT
CATAATGCTGGAGCGGCTGCGGCACAAAGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8663.97 Da        Isoelectric Point: 8.7848

>AT170425 WP_015463213.1 NZ_CP060453:c2659215-2658982 [Xanthomonas citri pv. citri]
MQVAKWGNSLAVRLPSSLVEALELREGDDIEIVVDDPRLFAVRKKPGPEAMLERLRAFRGKLPADFKFNRDEANGRG

Download         Length: 234 bp

>AT170425 NZ_CP077366:2609161-2609409 [Pantoea agglomerans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTCATTCGTCAGCGCAATGGCTGGACCCAGAGTGAACTGGC
GAAAAAGGTCGGCCTGAAACAGGCCACCATCTCTCACTTTGAAAATGCCCCTGACAGTACCTCGCTGGCAACGCTGTTTA
AGCTGTTACAGTCGCTGGAGCTGAGTCTGGAAGTTCAGGAGAAAGAGGAGGCCGGTGCGCCTCAGCTGCATGATGAGGAT
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB M4TWF0

References