Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5110603..5111270 Replicon chromosome
Accession NZ_CP060446
Organism Xanthomonas citri pv. citri strain DAR72029

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag H8Z73_RS21810 Protein ID WP_005916679.1
Coordinates 5110854..5111270 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag H8Z73_RS21805 Protein ID WP_005916676.1
Coordinates 5110603..5110857 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z73_RS21780 5106713..5106932 + 220 Protein_4256 RNA 2'-phosphotransferase -
H8Z73_RS21785 5107101..5108366 + 1266 WP_040280600.1 cardiolipin synthase B -
H8Z73_RS21790 5108392..5108919 - 528 WP_005916668.1 hypothetical protein -
H8Z73_RS21795 5109158..5109364 + 207 WP_003489327.1 hypothetical protein -
H8Z73_RS21800 5109351..5110457 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8Z73_RS21805 5110603..5110857 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
H8Z73_RS21810 5110854..5111270 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
H8Z73_RS21815 5111392..5111595 - 204 WP_125460668.1 hypothetical protein -
H8Z73_RS21820 5111723..5111935 - 213 WP_015472901.1 hypothetical protein -
H8Z73_RS21825 5112192..5113811 + 1620 WP_015463800.1 hypothetical protein -
H8Z73_RS21830 5113915..5114313 - 399 WP_004429277.1 DUF2384 domain-containing protein -
H8Z73_RS21835 5114629..5115060 + 432 WP_005922907.1 hypothetical protein -
H8Z73_RS21840 5115089..5115415 - 327 Protein_4268 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T170420 WP_005916679.1 NZ_CP060446:5110854-5111270 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T170420 NZ_CP077338:170618-170911 [Acinetobacter lwoffii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGCCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT170420 WP_005916676.1 NZ_CP060446:5110603-5110857 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT170420 NZ_CP077338:170383-170628 [Acinetobacter lwoffii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References