Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4711522..4711883 Replicon chromosome
Accession NZ_CP060446
Organism Xanthomonas citri pv. citri strain DAR72029

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag H8Z73_RS20225 Protein ID WP_005914328.1
Coordinates 4711522..4711656 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag H8Z73_RS20230 Protein ID WP_003486606.1
Coordinates 4711731..4711883 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z73_RS20205 4706665..4708351 - 1687 Protein_3950 M20/M25/M40 family metallo-hydrolase -
H8Z73_RS20210 4708543..4709577 - 1035 WP_011052671.1 MBL fold metallo-hydrolase -
H8Z73_RS20215 4709616..4710905 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
H8Z73_RS20220 4711086..4711295 - 210 WP_003486601.1 CsbD family protein -
H8Z73_RS20225 4711522..4711656 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
H8Z73_RS20230 4711731..4711883 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
H8Z73_RS20235 4711990..4712913 - 924 WP_005927745.1 arginase -
H8Z73_RS20240 4713234..4713686 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
H8Z73_RS20245 4713750..4714109 + 360 WP_003486613.1 hypothetical protein -
H8Z73_RS20250 4714206..4715123 + 918 WP_011052673.1 hypothetical protein -
H8Z73_RS20255 4715120..4715662 + 543 WP_003486615.1 GTPase -
H8Z73_RS20260 4716100..4716783 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T170419 WP_005914328.1 NZ_CP060446:c4711656-4711522 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T170419 NZ_CP077338:167883-168173 [Acinetobacter lwoffii]
ATGGTTAAAGTAGCTGATTTACCAAGTTTTGATATGGCTGAGTCACTCAAAACTGAAGAAGACATTGTGATTTATCTCAA
TATGGTTCTTGAAGAGAATGATCCAGCTGAATTAGCTCATGCACTTGGTGTTATTGCTAAAGCTCGTGGCATGACTCAAA
TCGCTAAAGAAGCAGGGATTGGGCGTGAGGCACTCTACAAAGCCCTACGTCATGATTCAGCACCACGTTTTGATACAATT
AATCGTGTAGTAAATGCTTTAGGCTTAAAACTCACAGTACAACACGCCTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT170419 WP_003486606.1 NZ_CP060446:c4711883-4711731 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT170419 NZ_CP077338:167585-167881 [Acinetobacter lwoffii]
ATGATTGAAATTAAACGTCTGCCAGAATTTGATGAATGGTTGGATGGCATTAAAGACAATATGACCCGTATCCGCCTGAA
TCGTCGATTAGATAAGGTTCAACGTGGAAACTGGGGAGACATTAAACCTCTCCAAGATGGCGTTTGGGAAATGAGAGAAT
TCTTCGGTTCTGGATGGAGGATGTATTACATCCAACATGGTGACGTTGTGATTGTAATGCTTGGTGGTGGAGATAAATCA
ACTCAACAACAAGACATCGATCGTGCAGTCAAACTATCGAAAACGTTGGAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References