170414

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4557977..4558631 Replicon chromosome
Accession NZ_CP060441
Organism Citrobacter cronae strain S175-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A2Z3X2B8
Locus tag H3W50_RS22515 Protein ID WP_038633481.1
Coordinates 4558224..4558631 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag H3W50_RS22510 Protein ID WP_016154349.1
Coordinates 4557977..4558243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3W50_RS22485 (4553176) 4553176..4554609 - 1434 WP_038633498.1 6-phospho-beta-glucosidase BglA -
H3W50_RS22490 (4554730) 4554730..4555458 - 729 WP_038633495.1 MurR/RpiR family transcriptional regulator -
H3W50_RS22495 (4555511) 4555511..4555822 + 312 WP_038633492.1 N(4)-acetylcytidine aminohydrolase -
H3W50_RS22500 (4555986) 4555986..4556645 + 660 WP_038633489.1 hemolysin III family protein -
H3W50_RS22505 (4556740) 4556740..4557720 - 981 WP_038633486.1 tRNA-modifying protein YgfZ -
H3W50_RS22510 (4557977) 4557977..4558243 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
H3W50_RS22515 (4558224) 4558224..4558631 + 408 WP_038633481.1 protein YgfX Toxin
H3W50_RS22520 (4558732) 4558732..4559253 - 522 WP_038633478.1 flavodoxin FldB -
H3W50_RS22525 (4559367) 4559367..4560263 + 897 WP_038633475.1 site-specific tyrosine recombinase XerD -
H3W50_RS22530 (4560287) 4560287..4561000 + 714 WP_038633473.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H3W50_RS22535 (4561006) 4561006..4562739 + 1734 WP_038633470.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15944.81 Da        Isoelectric Point: 11.2845

>T170414 WP_038633481.1 NZ_CP060441:4558224-4558631 [Citrobacter cronae]
VVQWQSDLRVSWRAQWLSLLVHGLVAVFILLMPWPLSYTPLWMVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMVKTGMMLRLRSDTGKRQHLWLAADSMDEAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

>T170414 NZ_CP077336:1931317-1931703 [Acinetobacter lwoffii]
ATGGATAATCGTTGCTTCAAGCTGAAACGCAGTCTGTGTGCATTGGCGTTTCAGCTGTTTATTTTTGCACTGCTGATGTA
TCTGTTGTATCAGTTATTACCGATTGCAATTTGGGCAGTATGTGTTGTCATAGGCTTGGTAATTTATCAGCTGTTTTATC
GTAAGACGCCACAGATAGAGCAGTTTGAATATCTCGATGGACGTGAATGGTCCTTGACTACCAAAGCACGACCGACCCGT
CGGGTATTCATCAGTCATGTCATTGATCATCAGGCGTATATTGTGGTGTATTTCCAGCATGCCAAGGCGCGACCTTTACT
GATCTGGTGTGATCAATTGCCGTTCAAACAATGGAAGTCTTTAAAAGTACTGACTAAATTAGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT170414 WP_016154349.1 NZ_CP060441:4557977-4558243 [Citrobacter cronae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170414 NZ_CP077336:1931067-1931324 [Acinetobacter lwoffii]
ATGACTGATGACATTAGCTTGGAAGAGCGCAAGGTGATTTATCGTGCGCGTCGTGGTCTAAAAGAACTGGATGTATATTT
TGATCCCTACGTCAAAAACTACTACCTGAATGCTGAGCCTTTCGAAAAGCAGATGTTCGCAGAACTGGTTGAGCAGGAAG
ACCCGGATTTGCTGGACTGGTTTATGGAAGTGTCCGAGCCGCCACGCCCTGAACTAAAAGATTTTATCAAGAAGCTTAAA
TTTTACGTTCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3X2B8

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References