Detailed information of TA system TA170412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4425397..4427095
• Replicon: chromosome
• Accession: NZ_CP060441
• Organism: Citrobacter cronae strain S175-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: H3W50_RS21820
• Protein ID: WP_038633789.1
• Coordinates: 4425397..4426326 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: H3W50_RS21825
• Protein ID: WP_038633786.1
• Coordinates: 4426313..4427095 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3W50_RS21805 (4421065)	4421065..4421727	+	663	WP_230592261.1	VasL domain-containing protein	-
H3W50_RS21810 (4422487)	4422487..4424013	+	1527	WP_230592259.1	SbcC/MukB-like Walker B domain-containing protein	-
H3W50_RS21815 (4424015)	4424015..4425172	+	1158	WP_038633793.1	DUF3322 domain-containing protein	-
H3W50_RS21820 (4425397)	4425397..4426326	-	930	WP_038633789.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H3W50_RS21825 (4426313)	4426313..4427095	-	783	WP_038633786.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
H3W50_RS21830 (4427361)	4427361..4430576	+	3216	WP_038633783.1	RNA-directed DNA polymerase	-
H3W50_RS21835 (4430900)	4430900..4431361	+	462	Protein_4263	hypothetical protein	-
H3W50_RS21840 (4431358)	4431358..4431564	+	207	WP_038633780.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4419678..4443789	24111

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-275)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35090.30 Da
• Isoelectric Point: 5.4632

>T170412 WP_038633789.1 NZ_CP060441:c4426326-4425397 [Citrobacter cronae]
MDLRDSYARQVRLLMTALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDSDLAAINDALMRITESLNGR
PGINAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPATEMPVCEQVEMEYGFTTMNVVSQADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWETARIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
QSHLTDRDRQFLLSYKQNTPDWSLYRYPEIQHLPAIRWKLRNLAVLKEKNPAKYAATVNKLEGVLEQYF

Nucleotide

• Length: 930 bp

>T170412 NZ_CP077333:c86802-86425 [Lelliottia amnigena]
ATGGCCGACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCTACAGGGATCTGATGGCGTTGTCGCCCGATGTGCGACG
GCGTTTCGGTTACGCGCTGTCGCTGGCCCAGATGGGCGACCAGGACGACGCGGCCAAGGTGCTCAAGGGCTTCGGCGGGG
CTGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACGTACCGGGCGGTCTACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGGATCGCCACGCCGAAGGTGGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGCAATGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29385.59 Da
• Isoelectric Point: 8.6064

>AT170412 WP_038633786.1 NZ_CP060441:c4427095-4426313 [Citrobacter cronae]
MPNYINWLMQNTLPGQVLLQSWLTRSGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWERPVRVAGLT
SLALQGHAHYTEPGRQQIWLALPAYVKLPGWFAAFEQSAMFVTLYTSGLTVDIPSFTTQLNIGDRQLTGSVPELAAYEIA
YGVPSFISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVLLYLARRNAHPYFRHLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT170412 NZ_CP077333:c86444-86109 [Lelliottia amnigena]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGCTCAACGAAGCTCGGGCAACGTCTTCGCCGACCTGGGGCTGCCCGATGC
CGAAAAGCTGAAGATCAAGACCGGCCTGGTCATCGAGATCAGGAAGGCGATGCGCGCCCTTGACCTGACGCAACAAGCGG
CGGCCAAGCGTATGGGCATCCCGCAACCGAAGGTATCGGGCATGATGCACGGCGACTTCACCAACCTGTCCGAGCGCAAG
CTGATGGACTGCCTGAACCGCCTCGGCTACGACATCGAAATCAAGGTGCGGCCGGCAACCGAGCCGGTCGGCCACCTGAC
GCTTGCAACCGCCTGA