Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3632437..3633238 | Replicon | chromosome |
| Accession | NZ_CP060441 | ||
| Organism | Citrobacter cronae strain S175-1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A376QBB8 |
| Locus tag | H3W50_RS17825 | Protein ID | WP_038635535.1 |
| Coordinates | 3632437..3632814 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | H3W50_RS17830 | Protein ID | WP_089627953.1 |
| Coordinates | 3632861..3633238 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H3W50_RS17795 (3628511) | 3628511..3628888 | - | 378 | Protein_3470 | DUF4942 domain-containing protein | - |
| H3W50_RS17800 (3628973) | 3628973..3629719 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| H3W50_RS17805 (3629734) | 3629734..3631275 | - | 1542 | Protein_3472 | IS21-like element ISEc12 family transposase | - |
| H3W50_RS17810 (3631470) | 3631470..3631658 | - | 189 | Protein_3473 | restriction endonuclease subunit M | - |
| H3W50_RS17815 (3631743) | 3631743..3631985 | - | 243 | WP_012777794.1 | DUF957 domain-containing protein | - |
| H3W50_RS17820 (3631952) | 3631952..3632440 | - | 489 | WP_038635538.1 | DUF5983 family protein | - |
| H3W50_RS17825 (3632437) | 3632437..3632814 | - | 378 | WP_038635535.1 | TA system toxin CbtA family protein | Toxin |
| H3W50_RS17830 (3632861) | 3632861..3633238 | - | 378 | WP_089627953.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H3W50_RS17835 (3633314) | 3633314..3633535 | - | 222 | WP_000692306.1 | DUF987 domain-containing protein | - |
| H3W50_RS17840 (3633604) | 3633604..3634080 | - | 477 | WP_001186768.1 | RadC family protein | - |
| H3W50_RS17845 (3634096) | 3634096..3634569 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| H3W50_RS17850 (3634663) | 3634663..3634908 | - | 246 | WP_000680586.1 | hypothetical protein | - |
| H3W50_RS17855 (3634908) | 3634908..3635729 | - | 822 | WP_038635526.1 | DUF932 domain-containing protein | - |
| H3W50_RS17860 (3635829) | 3635829..3636002 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| H3W50_RS17865 (3636122) | 3636122..3636364 | - | 243 | WP_230592266.1 | DNA polymerase III subunit gamma/tau | - |
| H3W50_RS17875 (3637354) | 3637354..3638192 | - | 839 | Protein_3486 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14016.93 Da Isoelectric Point: 7.3223
>T170411 WP_038635535.1 NZ_CP060441:c3632814-3632437 [Citrobacter cronae]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T170411 NZ_CP077333:c60404-60027 [Lelliottia amnigena]
ATGGCCGACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCTACAGGGATCTGATGGCGTTGTCGCCCGATGTGCGACG
GCGTTTCGGTTACGCGCTGTCGCTGGCCCAGATGGGCGACCAGGACGACGCGGCCAAGGTGCTCAAGGGCTTCGGCGGGG
CTGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACGTACCGGGCGGTCTACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGGATCGCCACGCCGAAGGTGGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGCAATGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
ATGGCCGACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCTACAGGGATCTGATGGCGTTGTCGCCCGATGTGCGACG
GCGTTTCGGTTACGCGCTGTCGCTGGCCCAGATGGGCGACCAGGACGACGCGGCCAAGGTGCTCAAGGGCTTCGGCGGGG
CTGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACGTACCGGGCGGTCTACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGGATCGCCACGCCGAAGGTGGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGCAATGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13812.62 Da Isoelectric Point: 5.8746
>AT170411 WP_089627953.1 NZ_CP060441:c3633238-3632861 [Citrobacter cronae]
VSDTLPGTTHPDDNHDRPWWGGPCTVTPCFGARLVQEGNRLHYLVDRAGIRGRFSDADAYHLDQAFLLLMKQLELMLTSG
ELNPRHQHTVTLYAKELTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGGPCTVTPCFGARLVQEGNRLHYLVDRAGIRGRFSDADAYHLDQAFLLLMKQLELMLTSG
ELNPRHQHTVTLYAKELTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT170411 NZ_CP077333:c60046-59711 [Lelliottia amnigena]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGCTCAACGAAGCTCGGGCAACGTCTTCGCCGACCTGGGGCTGCCCGATGC
CGAAAAGCTGAAGATCAAGACCGGCCTGGTCATCGAGATCAGGAAGGCGATGCGCGCCCTTGACCTGACGCAACAAGCGG
CGGCCAAGCGTATGGGCATCCCGCAACCGAAGGTATCGGGCATGATGCACGGCGACTTCACCAACCTGTCCGAGCGCAAG
CTGATGGACTGCCTGAACCGCCTCGGCTACGACATCGAAATCAAGGTGCGGCCGGCAACCGAGCCGGTCGGCCACCTGAC
GCTTGCAACCGCCTGA
ATGCAAAAACGAATCATTGAAGGCGTCGAGGCTCAACGAAGCTCGGGCAACGTCTTCGCCGACCTGGGGCTGCCCGATGC
CGAAAAGCTGAAGATCAAGACCGGCCTGGTCATCGAGATCAGGAAGGCGATGCGCGCCCTTGACCTGACGCAACAAGCGG
CGGCCAAGCGTATGGGCATCCCGCAACCGAAGGTATCGGGCATGATGCACGGCGACTTCACCAACCTGTCCGAGCGCAAG
CTGATGGACTGCCTGAACCGCCTCGGCTACGACATCGAAATCAAGGTGCGGCCGGCAACCGAGCCGGTCGGCCACCTGAC
GCTTGCAACCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|