Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2922369..2922888 Replicon chromosome
Accession NZ_CP060441
Organism Citrobacter cronae strain S175-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2Z3WY74
Locus tag H3W50_RS14345 Protein ID WP_038636706.1
Coordinates 2922369..2922650 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2Z3X2E3
Locus tag H3W50_RS14350 Protein ID WP_038636704.1
Coordinates 2922640..2922888 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3W50_RS14330 (2919371) 2919371..2919835 + 465 WP_038636713.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H3W50_RS14335 (2919857) 2919857..2920378 - 522 WP_038636711.1 toxin-antitoxin system YwqK family antitoxin -
H3W50_RS14340 (2920378) 2920378..2922342 - 1965 WP_038636709.1 type VI secretion system tip protein TssI/VgrG -
H3W50_RS14345 (2922369) 2922369..2922650 - 282 WP_038636706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3W50_RS14350 (2922640) 2922640..2922888 - 249 WP_038636704.1 plasmid stabilization protein Antitoxin
H3W50_RS14355 (2923036) 2923036..2923671 - 636 WP_129694863.1 hypothetical protein -
H3W50_RS14360 (2923697) 2923697..2926219 - 2523 WP_038636701.1 type VI secretion system ATPase TssH -
H3W50_RS14365 (2926210) 2926210..2927154 - 945 WP_038642979.1 type VI secretion system baseplate subunit TssG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.76 Da        Isoelectric Point: 10.4466

>T170409 WP_038636706.1 NZ_CP060441:c2922650-2922369 [Citrobacter cronae]
MTYSLEFLDIALKEWRKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Download         Length: 282 bp

>T170409 NZ_CP077331:4223464-4223877 [Lelliottia amnigena]
GTGGTCCTGTGGCAATCTGATCTGCGCGTATCCTGGCGCTCACAGTGGATGTCTTTGTTGCTCCACGGAATGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCACTCAGCTACACCCCGTTATGGATGCTGTTACTCTCGCTTGTGGTGTTCGACAGCG
TGCGCAGCCAGCGACGTATCAATTCCTGTCAGGGCGAAATCAAGCTGCTGATGGACTCTCGTCTACGCTGGCAAGGTAAA
GAGTGGGAAATCGTCGGTACGCCCTGGATGCTGAGTTTTGGCATGATGTTTCGCTTGCGTAACGTGCAAGGCGGACGAAA
CCAGCATTTATGGCTTTCGGCGGACAGTATGGATGCTGACGAGTGGCGAGATTTGCGTCGGATGGTTTTGCAGCAACCGA
CGCCCGGTCGATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8987.23 Da        Isoelectric Point: 4.5338

>AT170409 WP_038636704.1 NZ_CP060441:c2922888-2922640 [Citrobacter cronae]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIQVSLN
DL

Download         Length: 249 bp

>AT170409 NZ_CP077331:4223217-4223483 [Lelliottia amnigena]
ATGGACATTAGCAATAAGGCTCGTATTCACTGGGCGTGCCGCCGCGGCATGCGCGAACTTGATATTTCCGTCATGCCATT
CTTCGAATATGAATACGACAGCTTAAGCGATGACGATAAGCGTCTGTTTATTCGCCTTCTTGAAAGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3WY74

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3X2E3

References