Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1254375..1255014 Replicon chromosome
Accession NZ_CP060441
Organism Citrobacter cronae strain S175-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H3W50_RS06200 Protein ID WP_038640738.1
Coordinates 1254838..1255014 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H3W50_RS06195 Protein ID WP_087856629.1
Coordinates 1254375..1254791 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3W50_RS06175 (1249420) 1249420..1250364 - 945 WP_038640728.1 ABC transporter permease -
H3W50_RS06180 (1250365) 1250365..1251381 - 1017 WP_038640730.1 ABC transporter ATP-binding protein -
H3W50_RS06185 (1251398) 1251398..1252543 - 1146 WP_038640732.1 ABC transporter substrate-binding protein -
H3W50_RS06190 (1252873) 1252873..1254282 - 1410 WP_038640734.1 PLP-dependent aminotransferase family protein -
H3W50_RS06195 (1254375) 1254375..1254791 - 417 WP_087856629.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H3W50_RS06200 (1254838) 1254838..1255014 - 177 WP_038640738.1 type II toxin-antitoxin system HicA family toxin Toxin
H3W50_RS06205 (1255279) 1255279..1256682 + 1404 WP_038640740.1 cytochrome ubiquinol oxidase subunit I -
H3W50_RS06210 (1256682) 1256682..1257692 + 1011 WP_038640742.1 cytochrome d ubiquinol oxidase subunit II -
H3W50_RS06215 (1257692) 1257692..1257817 + 126 WP_064507023.1 DUF2474 domain-containing protein -
H3W50_RS06220 (1258007) 1258007..1258237 + 231 WP_038640744.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-56)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6809.87 Da        Isoelectric Point: 11.6208

>T170400 WP_038640738.1 NZ_CP060441:c1255014-1254838 [Citrobacter cronae]
VKQSEFRRWLESQGVKVTNGSNHLKLRYQGRRSVMPRHPVDEIKEALRKAIQKQPGLQ

Download         Length: 177 bp

>T170400 NZ_CP077331:2855204-2855515 [Lelliottia amnigena]
ATGCACGTCATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCACTACCCAAACGATTCGTTAGCCCTTCTGGCGTTGTA
TCGCTTACTCCGTGAGACAGATTTTATTTCACCGACAGAACTGAGAACGTTAATACCGAGTCTGGATAATTTTAAGTATC
GAAGTAAATGGTGGGTAATAGATGTGGGTGGCAATAACTTGAGGATTGTCGCTTATATCAATTTTGTGAATAAACGCTTT
TACGTGAAGCATATCGTCACCCACTCTGAATACGATAAGTTGAACCGCTACTACAGGGAAAACAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.35 Da        Isoelectric Point: 4.5468

>AT170400 WP_087856629.1 NZ_CP060441:c1254791-1254375 [Citrobacter cronae]
MRYPVNLIPAVEGGFMVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT170400 NZ_CP077331:2855512-2855931 [Lelliottia amnigena]
ATGATCGCTAATACAGCAAGAGCCATTGAGGCCACCAAACAACTCGTCGATGCCGTCCCTTTCCTGGGGGGCAGTTCTTC
AGAGAGTGATTATCGCGAAGCCCTGGCGCTAGTGGATTATCTGATCGAGAACGACGATGAAAATCCCCTGATTGACTTCC
TCGCGAGCAAAATTGCCGACTATGAAAATAATAGCGACCGCTTCGCTGAGTTTAATAAATCTGTCGCTGAAATGCCTGTC
GGGGTTGCTCTGCTGCGCACGCTGATCGATCAGTACAAGCTTTCTTACGCTGATCTGAAAGAAGAGATTGGTTCGAAATC
ACTGGTCAGCCAGATCTTATCCGGACAACGCTCTCTGACCATCACCCACATTAAAGCGCTTTCTGCACGCTTCGGCGTGA
GACCGGAATGGTTCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References