Detailed information of TA system TA170395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4262166..4262701
• Replicon: chromosome
• Accession: NZ_CP060440
• Organism: Serratia marcescens strain M158-1-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: H3V66_RS20590
• Protein ID: WP_033636570.1
• Coordinates: 4262166..4262441 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H3V66_RS20595
• Protein ID: WP_047025978.1
• Coordinates: 4262441..4262701 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3V66_RS20570	4257984..4258976	-	993	WP_240023327.1	acyltransferase	-
H3V66_RS20575	4259194..4260441	+	1248	WP_049202603.1	MFS transporter	-
H3V66_RS20580	4260495..4261121	-	627	WP_240023328.1	LysE family translocator	-
H3V66_RS20585	4261243..4262154	+	912	WP_049202575.1	LysR family transcriptional regulator	-
H3V66_RS20590	4262166..4262441	-	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3V66_RS20595	4262441..4262701	-	261	WP_047025978.1	ribbon-helix-helix domain-containing protein	Antitoxin
H3V66_RS20600	4262784..4264625	-	1842	WP_240023329.1	selenocysteine-specific translation elongation factor	-
H3V66_RS20605	4264622..4266016	-	1395	WP_240023330.1	L-seryl-tRNA(Sec) selenium transferase	-
H3V66_RS20610	4266085..4266690	-	606	WP_038875954.1	glutathione S-transferase	-
H3V66_RS20615	4266731..4267381	-	651	WP_049274320.1	DcrB-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T170395 WP_033636570.1 NZ_CP060440:c4262441-4262166 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T170395 NZ_CP077318:98181-98456 [Providencia rettgeri]
ATGTTAACTCCTATTCGTTCTAGTACTTTTAAGGCTGATGTTAAGCGACAAAAAAAAAGAGGTAAGGATTTAAACAAGCT
AAAAGTATTAATTGAGTTACTAATAAAGGAAGAACAGATCCCTGCGGACTATGTAGACCACCCTTTAATAGGTAATTGGC
GAGGATATAGAGATGCTCATATTGAAGGTGATTGGCTACTAATTTATAAAATTACTGGTCAAGAATTAAAGTTAGCGAGA
ACGGGTTCTCACCAAGATATTTTCAGCCAATATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9667.98 Da
• Isoelectric Point: 4.5201

>AT170395 WP_047025978.1 NZ_CP060440:c4262701-4262441 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT170395 NZ_CP077318:97924-98187 [Providencia rettgeri]
ATGATTTCTGATACGACTGTTAAAGCTAGAATTTCTCACGATGTCAAAGAACGAGCTGTATCTGCACTTGCTAAGATGGG
CTTAAATACATCTGATCTTATCCGTATGGTTATGATTCGTGTTGCCGATGAAGGAAAACTACCATTTGATATCAAAACAC
CAAATGTTGTGACTAAAGAGGCAATTGAAGAATTAGAAAAAGGGAACGGAAAAGCATTATCTTCAACCAATGCACTTTTC
GATGATTTGGGGATCTGATGTTAA

Structures

Toxin

• AlphaFold DB: A0A5C7D971