Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1313913..1314541 Replicon chromosome
Accession NZ_CP060440
Organism Serratia marcescens strain M158-1-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H3V66_RS06295 Protein ID WP_074188547.1
Coordinates 1314338..1314541 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H3V66_RS06290 Protein ID WP_240023876.1
Coordinates 1313913..1314326 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V66_RS06260 1309143..1309865 + 723 WP_240023874.1 RNA polymerase sigma factor FliA -
H3V66_RS06265 1309921..1310430 + 510 WP_004934751.1 flagella biosynthesis regulatory protein FliZ -
H3V66_RS06270 1310557..1311549 + 993 WP_025303239.1 D-cysteine desulfhydrase -
H3V66_RS06275 1311665..1312465 + 801 WP_240023875.1 cystine ABC transporter substrate-binding protein -
H3V66_RS06280 1312465..1313127 + 663 WP_041035592.1 cystine ABC transporter permease -
H3V66_RS06285 1313131..1313883 + 753 WP_038876913.1 L-cystine ABC transporter ATP-binding protein TcyN -
H3V66_RS06290 1313913..1314326 - 414 WP_240023876.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H3V66_RS06295 1314338..1314541 - 204 WP_074188547.1 type II toxin-antitoxin system HicA family toxin Toxin
H3V66_RS06300 1314705..1318676 - 3972 WP_240023877.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliS / fliA / fliZ 1305554..1325797 20243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7507.89 Da        Isoelectric Point: 11.1475

>T170382 WP_074188547.1 NZ_CP060440:c1314541-1314338 [Serratia marcescens]
VKSAELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPKKDLKLGTLRQILKDAGLSALHIATR

Download         Length: 204 bp

>T170382 NZ_CP077308:3290759-3290977 [Enterobacter hormaechei]
ATGTCTGAAAAACCATTAACGAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGCCTTGCTGAAC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14949.62 Da        Isoelectric Point: 5.4927

>AT170382 WP_240023876.1 NZ_CP060440:c1314326-1313913 [Serratia marcescens]
MFYPAYIHTESNGSASGFFPDVPGCYFAGASLDDAFADAQSALDSHFELLSEDNQPIPRPHAVAAHLAKGAESFEGGQWL
LVAINMDKFDGRSERINITLPHRLLSRIDSRVQQHPGYGSRSGFLAAAARNELLKTE

Download         Length: 414 bp

>AT170382 NZ_CP077308:3290357-3290731 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAATCATGGCTGGGTAAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATTGAGC
ATATCGCTACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCAAACCCGGTTAGTCTTTCCTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References