Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1271596..1272227 Replicon chromosome
Accession NZ_CP060440
Organism Serratia marcescens strain M158-1-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H3V66_RS06040 Protein ID WP_049271803.1
Coordinates 1271829..1272227 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H3V66_RS06035 Protein ID WP_038876822.1
Coordinates 1271596..1271829 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V66_RS06010 1266748..1268364 + 1617 WP_225527262.1 methyl-accepting chemotaxis protein -
H3V66_RS06015 1268402..1269274 + 873 WP_038876818.1 protein-glutamate O-methyltransferase CheR -
H3V66_RS06020 1269274..1270323 + 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
H3V66_RS06025 1270426..1270815 + 390 WP_004934862.1 chemotaxis response regulator CheY -
H3V66_RS06030 1270826..1271470 + 645 WP_004934858.1 protein phosphatase CheZ -
H3V66_RS06035 1271596..1271829 + 234 WP_038876822.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H3V66_RS06040 1271829..1272227 + 399 WP_049271803.1 type II toxin-antitoxin system VapC family toxin Toxin
H3V66_RS06045 1272354..1273505 + 1152 WP_240023864.1 flagellar biosynthesis protein FlhB -
H3V66_RS06050 1273498..1275576 + 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
H3V66_RS06055 1275576..1275980 + 405 WP_240023865.1 flagellar protein FlhE -
H3V66_RS06060 1275983..1276285 - 303 WP_038876832.1 DNA-binding transcriptional regulator -
H3V66_RS06065 1276282..1276653 - 372 WP_174135184.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14932.13 Da        Isoelectric Point: 8.4955

>T170381 WP_049271803.1 NZ_CP060440:1271829-1272227 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSSRPVVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T170381 NZ_CP077308:3149518-3149763 [Enterobacter hormaechei]
CTGGACGATCTTTACCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCCAGCCTGGA
CCGGATGAAATACCGGGAAAAATGGTGGGTCATTGAAGTGGGTGGCGGGCATCTAAGAGTAATGTTTTTTGCTGATTTTG
AGCGGGGAAAGATCTTCATCAAACACATCAGCACGCACGCAGAGTATGACAAGCTCACGGACTACTACCGGAGAACGAAA
GAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8943.94 Da        Isoelectric Point: 4.6127

>AT170381 WP_038876822.1 NZ_CP060440:1271596-1271829 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAEQHQREREDF

Download         Length: 234 bp

>AT170381 NZ_CP077308:3149760-3150179 [Enterobacter hormaechei]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAACCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTGGAGTATCTTATCGAGCACGACCCGGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTACGAAAACGAGTCCCCGGAATTTGCAGAATTTAACGCGCGTATTGCCAGTATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTGATGGATCAGTACCAACTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
GAGTCGGATCCTGAACGGACAGCGCACGTTAACGCTGGATCATATGCGTGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTTGGGAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References