Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 705419..705981 Replicon chromosome
Accession NZ_CP060440
Organism Serratia marcescens strain M158-1-1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H3V66_RS03290 Protein ID WP_038881250.1
Coordinates 705625..705981 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag H3V66_RS03285 Protein ID WP_004936539.1
Coordinates 705419..705628 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V66_RS03265 701568..701894 + 327 WP_174135638.1 phage holin, lambda family -
H3V66_RS03270 701884..702285 + 402 WP_038881240.1 M15 family metallopeptidase -
H3V66_RS03275 702282..702632 + 351 Protein_642 hypothetical protein -
H3V66_RS03280 703030..705309 + 2280 WP_240023677.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
H3V66_RS03285 705419..705628 + 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H3V66_RS03290 705625..705981 + 357 WP_038881250.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H3V66_RS03295 705990..706928 - 939 WP_240023678.1 homocysteine S-methyltransferase -
H3V66_RS03300 706918..708327 - 1410 WP_174135634.1 S-methylmethionine permease -
H3V66_RS03305 708505..709344 + 840 WP_240024345.1 ChaN family lipoprotein -
H3V66_RS03310 709447..710244 + 798 WP_171887773.1 TonB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13133.90 Da        Isoelectric Point: 4.9139

>T170378 WP_038881250.1 NZ_CP060440:705625-705981 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLAE

Download         Length: 357 bp

>T170378 NZ_CP077308:581747-582157 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
ATTGGTGTTACTGGTGCCGTGGCCACTTAGCTATACCCCGCTGTGGTTGCTATTACTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGACAGGGACGCCGTGGATGCTTAACACGGGGATGATGCTACGGCTGCGACGGGTTGAGGACAATCGTCG
CGAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCAGAGTGGCGTGATCTGCGCCGGTTGATTGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT170378 WP_004936539.1 NZ_CP060440:705419-705628 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT170378 NZ_CP077308:581500-581766 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAGCTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References