Detailed information of TA system TA170377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 615917..616573
• Replicon: chromosome
• Accession: NZ_CP060440
• Organism: Serratia marcescens strain M158-1-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: H3V66_RS02880
• Protein ID: WP_047730091.1
• Coordinates: 616184..616573 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H3V66_RS02875
• Protein ID: WP_240023649.1
• Coordinates: 615917..616180 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3V66_RS02860	612214..613119	-	906	WP_225527749.1	lipid kinase YegS	-
H3V66_RS02865	613586..614938	-	1353	WP_174135688.1	tRNA 5-hydroxyuridine modification protein YegQ	-
H3V66_RS02870	615240..615578	-	339	WP_038873760.1	YegP family protein	-
H3V66_RS02875	615917..616180	+	264	WP_240023649.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H3V66_RS02880	616184..616573	+	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
H3V66_RS02885	616581..617297	-	717	WP_240023650.1	two-component system response regulator BaeR	-
H3V66_RS02890	617297..618679	-	1383	WP_240023651.1	two-component system sensor histidine kinase BaeS	-
H3V66_RS02895	618676..620106	-	1431	WP_174135687.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T170377 WP_047730091.1 NZ_CP060440:616184-616573 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T170377 NZ_CP077308:421275-421616 [Enterobacter hormaechei]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTAGCACCCGTGGCTGTCTGGCAAATGCTACTGAC
CCGCCTGCTGAAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGAATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10036.27 Da
• Isoelectric Point: 4.6702

>AT170377 WP_240023649.1 NZ_CP060440:615917-616180 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAALLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT170377 NZ_CP077308:420937-421254 [Enterobacter hormaechei]
ATGACCCACATCAACTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACAGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCAGATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Structures

Toxin

• AlphaFold DB: A0A5C7DE55