Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 17422..18065 Replicon plasmid pIncFIB_pQil
Accession NZ_CP060425
Organism Klebsiella pneumoniae strain BA2105

Toxin (Protein)


Gene name vagD Uniprot ID A0A5Q9LNG2
Locus tag HBJ34_RS28885 Protein ID WP_048983057.1
Coordinates 17649..18065 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID R4IT22
Locus tag HBJ34_RS28880 Protein ID WP_016338373.1
Coordinates 17422..17652 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ34_RS28845 12647..13120 + 474 WP_004152341.1 YkgJ family cysteine cluster protein -
HBJ34_RS28850 13212..13442 + 231 WP_011977773.1 hypothetical protein -
HBJ34_RS28855 14334..15116 - 783 WP_004152340.1 site-specific integrase -
HBJ34_RS28860 15116..15448 - 333 WP_004152339.1 hypothetical protein -
HBJ34_RS28865 15455..15853 - 399 WP_004171440.1 hypothetical protein -
HBJ34_RS28870 15879..16208 - 330 WP_004152337.1 hypothetical protein -
HBJ34_RS28875 16236..16544 - 309 WP_004152336.1 hypothetical protein -
HBJ34_RS28880 17422..17652 + 231 WP_016338373.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HBJ34_RS28885 17649..18065 + 417 WP_048983057.1 type II toxin-antitoxin system VapC family toxin Toxin
HBJ34_RS28890 18106..18983 - 878 Protein_18 restriction endonuclease -
HBJ34_RS28895 19642..20919 + 1278 WP_016338369.1 HlyD family secretion protein -
HBJ34_RS28900 20909..23017 + 2109 WP_016338368.1 peptidase domain-containing ABC transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-181 - 1..47630 47630
- flank IS/Tn - - 11259..12527 1268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15022.52 Da        Isoelectric Point: 9.2957

>T170373 WP_048983057.1 NZ_CP060425:17649-18065 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVK

Download         Length: 417 bp

>T170373 NZ_CP077304:39084-39392 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGACGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8751.77 Da        Isoelectric Point: 4.3533

>AT170373 WP_016338373.1 NZ_CP060425:17422-17652 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWSSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT170373 NZ_CP077304:39433-39735 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTGGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LNG2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LN61

References