Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4862251..4862767 Replicon chromosome
Accession NZ_CP060421
Organism Klebsiella pneumoniae strain BA2105

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HBJ34_RS24280 Protein ID WP_002886902.1
Coordinates 4862251..4862535 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HBJ34_RS24285 Protein ID WP_002886901.1
Coordinates 4862525..4862767 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ34_RS24255 4857667..4857975 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
HBJ34_RS24260 4858060..4858233 + 174 WP_032408826.1 hypothetical protein -
HBJ34_RS24265 4858236..4858979 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HBJ34_RS24270 4859336..4861474 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HBJ34_RS24275 4861783..4862247 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HBJ34_RS24280 4862251..4862535 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBJ34_RS24285 4862525..4862767 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HBJ34_RS24290 4862845..4864755 - 1911 WP_166702436.1 BglG family transcription antiterminator -
HBJ34_RS24295 4864778..4865932 - 1155 WP_002886900.1 lactonase family protein -
HBJ34_RS24300 4865999..4866739 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T170369 WP_002886902.1 NZ_CP060421:c4862535-4862251 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T170369 NZ_CP077302:2315671-2315931 [Corynebacterium coyleae]
ATGATTCTGTCTTGGGACGAAGATGCCTGGGCCGAGTATGTCGAATGGCAAACCACGGACAAGCGTGTGCTCAAACGCAT
CAACATGCTCATCCGCGATATTCAACGCAACGGCAATCAAGGCATCGGCAAGCCTGAACCGCTCAAACATGAGCTCAGTG
GCTATTGGTCCCGGAGGATTACCAGCGAGCACCGACTCGTGTACAAAATGACCGAAACCGAGATCCGAATTGCGGCTTGT
CGCTACCACTACGGGGAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT170369 WP_002886901.1 NZ_CP060421:c4862767-4862525 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT170369 NZ_CP077302:2315414-2315674 [Corynebacterium coyleae]
ATGAAAGTCATGTCTTACTCGGAATCTCGTGCAAACTACGCGGAGGTTCTGAACACAGTTGTTGACGATTGCGAGGAGGT
CGTCATCACCCGTTCCGGCCACGATCCGGTTGTCATTGTCTCGCTGGCGGAATACGAATCGATGAAGGAGACCTCTTATT
TGCTTCAATCCCCAGCGAATGCTCGCGTACTCAAGGAGCGAATCGAACGCTTGGAAAAAGGAACGTCGGTTCAGAATGAG
CTCATCGAGGAAGATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References