Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4102112..4102731 Replicon chromosome
Accession NZ_CP060421
Organism Klebsiella pneumoniae strain BA2105

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HBJ34_RS20575 Protein ID WP_002892050.1
Coordinates 4102513..4102731 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HBJ34_RS20570 Protein ID WP_002892066.1
Coordinates 4102112..4102486 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ34_RS20560 4097264..4098457 + 1194 WP_166702206.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HBJ34_RS20565 4098480..4101626 + 3147 WP_166702204.1 multidrug efflux RND transporter permease subunit AcrB -
HBJ34_RS20570 4102112..4102486 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HBJ34_RS20575 4102513..4102731 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HBJ34_RS20580 4102890..4103456 + 567 WP_002892030.1 maltose O-acetyltransferase -
HBJ34_RS20585 4103428..4103568 - 141 WP_004147370.1 hypothetical protein -
HBJ34_RS20590 4103589..4104059 + 471 WP_002892026.1 YlaC family protein -
HBJ34_RS20595 4104034..4105485 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HBJ34_RS20600 4105586..4106284 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HBJ34_RS20605 4106281..4106421 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HBJ34_RS20610 4106421..4106684 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T170367 WP_002892050.1 NZ_CP060421:4102513-4102731 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T170367 NZ_CP077302:1934506-1934787 [Corynebacterium coyleae]
ATGATCCAGTCATTCGCTGACAAGGACACTGAGCGTCTGTGGAATCGAGAGCGGGTCCGCTCGATCGATTCCCGCATTCA
CTCAGTAGCGCTGCGCAAGCTTCGCCAGCTTGGGTACGCGCAGACTCTCGATGAGTTACGGATTCCTCCGGGAAGCCGGC
TCGAGGCCTTGAAAGGCGACCGGCGGGGTCAGTTCAGCATTCGAATCAACGACCAGTGGCGGATCTGTTTTCGGTGGTCC
GCCGCGGGGCCAGAGGAGGTTGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT170367 WP_002892066.1 NZ_CP060421:4102112-4102486 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT170367 NZ_CP077302:1934822-1935082 [Corynebacterium coyleae]
ATGGAGGACTTTCTCAAGGAAATGGAGATCACCCAGCACAAGCTGGCCGTCTCCATCGGCGTTCCGCCCCGCCGGATCAA
CGAAATTGTTCACGGTAAGCGCGCTGTAACCGCTGACACTGCCCTTCGTTTGGCGAAGTTTTTCGGGATGAGCCCCCAGT
TCTGGCTTGGGTTACAGGCCCAGTACGACCTGGATGTGGCAGAAGACAAAATCCTGGCGGAAATCGAACGGATTCAGCCG
CTCCAGGCTGCCTCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References