Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843035..843692 Replicon chromosome
Accession NZ_CP060421
Organism Klebsiella pneumoniae strain BA2105

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HBJ34_RS04335 Protein ID WP_002916310.1
Coordinates 843282..843692 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HBJ34_RS04330 Protein ID WP_002916312.1
Coordinates 843035..843301 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ34_RS04305 838191..839624 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HBJ34_RS04310 839743..840471 - 729 WP_062920457.1 MurR/RpiR family transcriptional regulator -
HBJ34_RS04315 840521..840832 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HBJ34_RS04320 840996..841655 + 660 WP_002916317.1 hemolysin III family protein -
HBJ34_RS04325 841806..842789 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HBJ34_RS04330 843035..843301 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HBJ34_RS04335 843282..843692 + 411 WP_002916310.1 protein YgfX Toxin
HBJ34_RS04340 843699..844220 - 522 WP_004144730.1 flavodoxin FldB -
HBJ34_RS04345 844321..845217 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HBJ34_RS04350 845240..845953 + 714 WP_062920458.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HBJ34_RS04355 845959..847692 + 1734 WP_062920459.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T170356 WP_002916310.1 NZ_CP060421:843282-843692 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T170356 NZ_CP077293:5010119-5010439 [Klebsiella aerogenes]
ATGAATACTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGAAAATGTTACTGAC
AATCCTGCTAGACCAGCACTATGGTCTCACGCTAAACGACACGCCGTTCAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCTGATGCCATAAATTTTCTGGTTGAACGCTATGAACTAGTTCGTATTGACCAAAAAGGCTTC
TCTGTGCAAGATCAAGAACCTTGGTTAACTTCTATGGATGTCCACCGAGCACGATTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT170356 WP_002916312.1 NZ_CP060421:843035-843301 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170356 NZ_CP077293:5009772-5010098 [Klebsiella aerogenes]
ATGTCATTAATACCAGCCCATGAATGGGGACTACAAAGAGAAATTGTTCCACGGTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTGCATTATCTGGCTGACAGGGCTAGTTTGATGGGCAATTTCAGCGATACGGAATGTTTCAAATTGAATGACG
CATTTCCACACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAACTGATCCCCTGTCACCAACACTGTGTCACT
CTCTACCACAACGGTTTTACCTGCGAAGCTGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCTGTTTACCCTACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References