Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1241206..1242123 | Replicon | chromosome |
| Accession | NZ_CP060420 | ||
| Organism | Bacillus velezensis strain J17-4 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | I2HQ15 |
| Locus tag | H8P15_RS06435 | Protein ID | WP_007407256.1 |
| Coordinates | 1241377..1242123 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | I2HQ14 |
| Locus tag | H8P15_RS06430 | Protein ID | WP_003154807.1 |
| Coordinates | 1241206..1241376 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H8P15_RS06395 (H8P15_06395) | 1236439..1238061 | + | 1623 | WP_032874601.1 | pyocin knob domain-containing protein | - |
| H8P15_RS06400 (H8P15_06400) | 1238074..1238445 | + | 372 | WP_032874603.1 | XkdW family protein | - |
| H8P15_RS06405 (H8P15_06405) | 1238450..1238647 | + | 198 | WP_032874605.1 | XkdX family protein | - |
| H8P15_RS06410 (H8P15_06410) | 1238704..1239465 | + | 762 | WP_032874607.1 | hypothetical protein | - |
| H8P15_RS06415 (H8P15_06415) | 1239517..1239780 | + | 264 | WP_003154815.1 | hemolysin XhlA family protein | - |
| H8P15_RS06420 (H8P15_06420) | 1239794..1240057 | + | 264 | WP_003154813.1 | phage holin | - |
| H8P15_RS06425 (H8P15_06425) | 1240071..1240949 | + | 879 | WP_032874609.1 | N-acetylmuramoyl-L-alanine amidase | - |
| H8P15_RS19435 | 1240984..1241109 | - | 126 | WP_003154809.1 | hypothetical protein | - |
| H8P15_RS06430 (H8P15_06430) | 1241206..1241376 | - | 171 | WP_003154807.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| H8P15_RS06435 (H8P15_06435) | 1241377..1242123 | - | 747 | WP_007407256.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| H8P15_RS06440 (H8P15_06440) | 1242228..1243226 | - | 999 | WP_032874611.1 | inorganic phosphate transporter | - |
| H8P15_RS06445 (H8P15_06445) | 1243239..1243856 | - | 618 | WP_032874614.1 | DUF47 domain-containing protein | - |
| H8P15_RS06450 (H8P15_06450) | 1244142..1245458 | - | 1317 | WP_032874616.1 | amino acid permease | - |
| H8P15_RS06455 (H8P15_06455) | 1245780..1246730 | + | 951 | WP_032874618.1 | ring-cleaving dioxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1194268..1299975 | 105707 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29077.57 Da Isoelectric Point: 4.7755
>T170354 WP_007407256.1 NZ_CP060420:c1242123-1241377 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG
Download Length: 747 bp
>T170354 NZ_CP077293:c4225049-4224639 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGTATGGATGCGGGAGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGTATGGATGCGGGAGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6676.74 Da Isoelectric Point: 10.9273
>AT170354 WP_003154807.1 NZ_CP060420:c1241376-1241206 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA
Download Length: 171 bp
>AT170354 NZ_CP077293:c4225296-4225030 [Klebsiella aerogenes]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|