Detailed information of TA system TA170350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1705137..1705798
• Replicon: chromosome
• Accession: NZ_CP060414
• Organism: Neisseria musculi strain NW831

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H7A79_RS08665
• Protein ID: WP_187000014.1
• Coordinates: 1705137..1705319 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H7A79_RS08670
• Protein ID: WP_187000015.1
• Coordinates: 1705382..1705798 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A79_RS08625	1700363..1700644	+	282	WP_187000006.1	hypothetical protein	-
H7A79_RS08630	1700634..1700999	+	366	WP_187000007.1	hypothetical protein	-
H7A79_RS08635	1701119..1701679	+	561	WP_187000008.1	hypothetical protein	-
H7A79_RS08640	1701681..1702028	+	348	WP_187000009.1	DUF551 domain-containing protein	-
H7A79_RS08645	1702034..1702318	+	285	WP_187000010.1	hypothetical protein	-
H7A79_RS08650	1702355..1702774	-	420	WP_187000011.1	hypothetical protein	-
H7A79_RS08655	1702932..1703798	+	867	WP_187000012.1	hypothetical protein	-
H7A79_RS08660	1704103..1705008	+	906	WP_187000013.1	phage antirepressor N-terminal domain-containing protein	-
H7A79_RS08665	1705137..1705319	+	183	WP_187000014.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7A79_RS08670	1705382..1705798	+	417	WP_187000015.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7A79_RS08675	1705867..1706880	-	1014	WP_187000016.1	site-specific integrase	-
H7A79_RS08685	1707255..1708154	+	900	WP_187000017.1	recombination-associated protein RdgC	-
H7A79_RS08690	1708605..1708847	-	243	WP_187000018.1	hypothetical protein	-
H7A79_RS08695	1708828..1709394	+	567	WP_135037338.1	dCTP deaminase	-
H7A79_RS08700	1709803..1710363	+	561	WP_187000019.1	DUF1440 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1662715..1709394	46679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6944.08 Da
• Isoelectric Point: 11.4763

>T170350 WP_187000014.1 NZ_CP060414:1705137-1705319 [Neisseria musculi]
MKYSEFRRWLISQGVEFTTQKRGSHQLIRLGNRTSVFPNHGSKEIGSGLVKKIKKDLNLK

Nucleotide

• Length: 183 bp

>T170350 NZ_CP077292:66962-67444 [Citrobacter farmeri]
ATGGGAATGAGAGCACCTGAACCTTTAACGCCCGGACACAACATTGCTGAATTTTGTTGTTCAGACCCGGGTCTTAATGA
ATGGCTGAAAAAGAAAGCATTAAAAAATCACAGCACCGGCATTTCCCGTGTCTATGTTATTTGTGCTGAAAATACGAATC
AGGTGATCGGGTATTATTGTCTTTCTTCCGGCAGCGTTCAGAGAAATACCGCACCGGGCCCATACCGACGTAATGCCCCG
GACTCACTTCCTGTTATTGTACTGGGCAGACTTGCTGTTGATCTGGCATATGCAGGAAAAGGGCTGGGTGTTGCATTACT
CAAGGATGCGATATACCGGACACAAAACATCGCTGTTCAGGTCGGTGTAAGAGCGTTAATTGTCCATGCGCTGAATGATG
AGGTGAAAAGCTTTTATACGAAATTTGCTTTTGAACCATCCTCAGTAAATCCATTAACGTTATTCTTTCCTGTTAAACTC
TGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15284.52 Da
• Isoelectric Point: 4.4910

>AT170350 WP_187000015.1 NZ_CP060414:1705382-1705798 [Neisseria musculi]
MLSYRYELTPDDNGTFLVTFPDIPEAVAVGEDKESAAIEALDGLLCALDGYFEDRRAIPLPSTEQGSDTVTLPALETAKV
LLLNEMIAQGVKKAEMARRLDVHMPQIDRLLDLRHNTKIDFLEKAAEKLGKHLSISFA

Nucleotide

• Length: 417 bp

>AT170350 NZ_CP077292:66693-66971 [Citrobacter farmeri]
ATGAAATCAGAAGCCAGAGAGGCCCCTATCAACATCCGGGCGAAAACATCCCAGCGTGACCTGATTGATATGGCGGCAAG
CCTTGTATCAAAATCACGTACCGACTTCGTACTCGAAGCCGCCTGCCGTGAGGCTCAGGACATCCTGCTGGACCAGCGCC
TGTTCATACTGGACGATCAACAATATGACGCGTTCCTGGCTGAACTTGATGCCCCCATAACCCCAGATCGGCAGGCCCGA
ATCAATGATTTGATGGGTCGCAAATCGCCATGGGAATGA