Detailed information of TA system TA170349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1684713..1685345
• Replicon: chromosome
• Accession: NZ_CP060414
• Organism: Neisseria musculi strain NW831

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H7A79_RS08520
• Protein ID: WP_186999985.1
• Coordinates: 1684713..1684889 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H7A79_RS08525
• Protein ID: WP_186999986.1
• Coordinates: 1684923..1685345 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A79_RS08490	1682067..1682339	-	273	WP_186999979.1	DUF1799 domain-containing protein	-
H7A79_RS08495	1682387..1682698	-	312	WP_186999980.1	hypothetical protein	-
H7A79_RS08500	1682747..1683388	-	642	WP_186999981.1	phage tail protein	-
H7A79_RS08505	1683451..1683798	-	348	WP_186999982.1	DUF3168 domain-containing protein	-
H7A79_RS08510	1683788..1684288	-	501	WP_186999983.1	hypothetical protein	-
H7A79_RS08515	1684291..1684611	-	321	WP_186999984.1	phage head closure protein	-
H7A79_RS08520	1684713..1684889	+	177	WP_186999985.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7A79_RS08525	1684923..1685345	+	423	WP_186999986.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7A79_RS08530	1685442..1685813	-	372	WP_186999987.1	site-specific DNA-methyltransferase	-
H7A79_RS08535	1686178..1686384	-	207	WP_186999988.1	hypothetical protein	-
H7A79_RS08540	1686601..1686909	-	309	WP_186999989.1	head-tail connector protein	-
H7A79_RS08545	1686896..1687144	-	249	WP_186999990.1	hypothetical protein	-
H7A79_RS08550	1687219..1688403	-	1185	WP_186999991.1	phage major capsid protein	-
H7A79_RS08555	1688400..1689053	-	654	WP_186999992.1	HK97 family phage prohead protease	-
H7A79_RS08560	1689034..1690272	-	1239	WP_186999993.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1662715..1709394	46679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6654.87 Da
• Isoelectric Point: 10.9862

>T170349 WP_186999985.1 NZ_CP060414:1684713-1684889 [Neisseria musculi]
MKQSEFLKWLIAQGVETREGTKHIKLFYNGKQSHLPRHPGKELKTGLVQGIKKQLGLK

Nucleotide

• Length: 177 bp

>T170349 NZ_CP077292:49677-49982 [Citrobacter farmeri]
ATGCAGTTCAGGGTTTACACCTATAAAAGAGAAAGCCGCTACAGCCTATTCGTGGACGTGCAGAGTAACATCATCGACAC
ACCCGGCCGCCGGATGATGATCCCTCTGGTCAGTGCCCGTCTGCTGTCTGACAAAATCACACGGGAACTGTACCCGGTGG
TGCATATCGGCGATGACAGTTATCGTCTGGTGACTACCGATATGGCCAGTGTGCCAGCTTCGGTGATCGGAGAAGAAGTG
AGCGACCTCAGTCACCGGGAGAATGACATCAAGAATGCTATTAACCTGATGTTCTGGGGGATATGA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15615.96 Da
• Isoelectric Point: 4.7650

>AT170349 WP_186999986.1 NZ_CP060414:1684923-1685345 [Neisseria musculi]
MFYPAAFTPAEEGGYVVTFPDIPEAITQGDDLTEAREMAADVLLSAMDFYFEDRRPVPLPSKPKKGEEWVALPASVFAKV
LLLNEMLAQNISNAELARRMEIRPQEVQRITNLNHTTKIDTIARALMQLGKHLTVNTVSA

Nucleotide

• Length: 423 bp

>AT170349 NZ_CP077292:49457-49675 [Citrobacter farmeri]
ATGAAGCAGCGTATTACTGTCACCATCGACAGCGACAACTATCAACTACTCAAATCGGCAGACGTGAATATCTCCGGGCT
GGTGAATACAGCCATGCAGAAAGAGGCCCGACGTCTGCGTGCTGAACGCTGGCAAGCTGAAAATCAGGAAGGGATGGCTG
AAGTCGCCCGGTTTATTGAAATGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA