Detailed information of TA system TA170348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1666690..1667341
• Replicon: chromosome
• Accession: NZ_CP060414
• Organism: Neisseria musculi strain NW831

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H7A79_RS08420
• Protein ID: WP_186999967.1
• Coordinates: 1666690..1666872 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H7A79_RS08425
• Protein ID: WP_186999968.1
• Coordinates: 1666925..1667341 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A79_RS08390	1662248..1662515	+	268	Protein_1640	lipopolysaccharide heptosyltransferase	-
H7A79_RS08395	1662512..1662841	+	330	Protein_1641	helix-turn-helix domain-containing protein	-
H7A79_RS08400	1662990..1663641	+	652	Protein_1642	IS1595 family transposase	-
H7A79_RS08405	1663660..1664187	+	528	Protein_1643	tyrosine-type recombinase/integrase	-
H7A79_RS08410	1664228..1664872	+	645	Protein_1644	IS1595 family transposase	-
H7A79_RS08415	1665002..1666369	+	1368	WP_186999966.1	exodeoxyribonuclease VII large subunit	-
H7A79_RS08420	1666690..1666872	+	183	WP_186999967.1	type II toxin-antitoxin system HicA family toxin	Toxin
H7A79_RS08425	1666925..1667341	+	417	WP_186999968.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H7A79_RS08430	1667406..1667609	-	204	WP_186999969.1	hypothetical protein	-
H7A79_RS08435	1667929..1668453	-	525	WP_186999970.1	hypothetical protein	-
H7A79_RS08440	1668453..1669112	-	660	WP_187001672.1	hypothetical protein	-
H7A79_RS08445	1669285..1669554	-	270	WP_186999971.1	hypothetical protein	-
H7A79_RS08450	1669551..1669967	-	417	WP_186999972.1	hypothetical protein	-
H7A79_RS08455	1670023..1670400	-	378	WP_186999973.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1662715..1709394	46679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6889.00 Da
• Isoelectric Point: 10.9086

>T170348 WP_186999967.1 NZ_CP060414:1666690-1666872 [Neisseria musculi]
MKYSEFRKWLLSQGVEFTTQKRGSHQLIRLGNKTSVFPNHGSKEIGTGLVNKIKKDLDLK

Nucleotide

• Length: 183 bp

>T170348 NZ_CP077292:c27351-26821 [Citrobacter farmeri]
ATGGACGGTTTAAGGATTGAGATTTTTTCTGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACTGCTCATCTGAAGCGCCAGCACAACAGTAAGATTTTACGCGGCTATCTGCTCGTGACGAGAGAGG
ATAAACCACGTGTTATGGGGTACTACACGTTGTCTGGCAGTTGCTTTGAGAAAACGCTGCTTCCCAGTAAGACACAACAA
AGGCGAGTGCTCTACAAAAACGTGCCGAGCGTGACTTTGGGTCGTCTGGCACTTGATAAAAGCATTCATCATCAGGGATA
TGGAGAAACACTTGTTACCCATGCTATGAAAATCGTGTATCAGGCCTCGCAAGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCAACTGGGTTTTATACAGTTAAAGGAAGAAAATTGTAATTCGCTT
TTCTACCCGACAAAATCGATTGAAGAATTGTTCGAAGTAAGAGATGAATAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15192.52 Da
• Isoelectric Point: 4.7852

>AT170348 WP_186999968.1 NZ_CP060414:1666925-1667341 [Neisseria musculi]
MLAYRYILTPDDNGTFLVTFPDIPEAVAVGEDEASAGIEAADGLICALEGYFADRREVPLPSGNDGRQVVVLPALETAKV
LLLNEMLAQNVKKAEMARRLDVHMPQIDRLLDLRHNTKIDFLEKAAGKLGKRLNISFS

Nucleotide

• Length: 417 bp

>AT170348 NZ_CP077292:c27624-27355 [Citrobacter farmeri]
ATGTCAGCACTGAAGAAGCAGCGCATAGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAGGCTGCAGCAAT
GACTAACCAGTCAATTTCACAGTTCATGGTCAGTACTGCTTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAACCTGGTTATGGAAGCAATCACTAATCCGCCGGCACCGAATGACCGACTGAAACGA
GCCGCTAAACGTCTCCAGGAACTGGAGTAA