Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1163780..1164439 Replicon chromosome
Accession NZ_CP060414
Organism Neisseria musculi strain NW831

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H7A79_RS05920 Protein ID WP_187001385.1
Coordinates 1164257..1164439 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H7A79_RS05915 Protein ID WP_187001384.1
Coordinates 1163780..1164196 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7A79_RS05855 1159477..1159983 - 507 WP_187001374.1 DUF1804 family protein -
H7A79_RS05860 1159985..1160200 - 216 WP_187001375.1 hypothetical protein -
H7A79_RS05865 1160211..1160474 - 264 WP_187001640.1 hypothetical protein -
H7A79_RS05870 1160480..1160821 - 342 WP_187001376.1 hypothetical protein -
H7A79_RS05875 1160818..1161135 - 318 WP_187001377.1 hypothetical protein -
H7A79_RS05880 1161032..1161439 - 408 WP_187001378.1 hypothetical protein -
H7A79_RS05885 1161417..1161647 - 231 WP_187001379.1 hypothetical protein -
H7A79_RS05890 1161659..1161844 - 186 WP_187001380.1 hypothetical protein -
H7A79_RS05895 1161848..1162057 - 210 WP_187001381.1 hypothetical protein -
H7A79_RS05900 1162057..1162590 - 534 WP_187001382.1 N-acetylmuramoyl-L-alanine amidase -
H7A79_RS05905 1162773..1163201 - 429 WP_187001383.1 mor transcription activator family protein -
H7A79_RS05910 1163191..1163601 - 411 WP_187001641.1 regulatory protein GemA -
H7A79_RS05915 1163780..1164196 - 417 WP_187001384.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H7A79_RS05920 1164257..1164439 - 183 WP_187001385.1 type II toxin-antitoxin system HicA family toxin Toxin
H7A79_RS05925 1164622..1164789 - 168 WP_187001386.1 hypothetical protein -
H7A79_RS05930 1165136..1165300 - 165 WP_187001387.1 DNA polymerase III -
H7A79_RS05935 1165304..1165957 - 654 WP_187001388.1 Bro-N domain-containing protein -
H7A79_RS05940 1166112..1166279 - 168 WP_187001389.1 hypothetical protein -
H7A79_RS05945 1166641..1167162 - 522 WP_187001390.1 host-nuclease inhibitor Gam family protein -
H7A79_RS05950 1167175..1167411 - 237 WP_187001391.1 hypothetical protein -
H7A79_RS05955 1167404..1167550 - 147 WP_187001392.1 hypothetical protein -
H7A79_RS05960 1167641..1167793 - 153 WP_187001393.1 hypothetical protein -
H7A79_RS05965 1167795..1168268 - 474 WP_187001394.1 hypothetical protein -
H7A79_RS05970 1168265..1168753 - 489 WP_187001395.1 hypothetical protein -
H7A79_RS05975 1168750..1168938 - 189 WP_187001396.1 hypothetical protein -
H7A79_RS05980 1168935..1169429 - 495 WP_187001397.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1130360..1175271 44911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6797.96 Da        Isoelectric Point: 11.0962

>T170347 WP_187001385.1 NZ_CP060414:c1164439-1164257 [Neisseria musculi]
VKYSEFRKWLLSQGVEFTTQKRGSHQLIRLGNKTSVFPNHGSKEIGTGLVLKIKKDLGLK

Download         Length: 183 bp

>T170347 NZ_CP077292:18690-18980 [Citrobacter farmeri]
ATGACCTTTAATGTTGAATTTGACGAAAGGGCGTTTAAAGAATGGAATAAGCTCGAAAAGACGATCCGCGAGCAATTCAA
AAAGAAGCTAAAAAAGCTTCAGCAAAACCCTTATGTGGAATCAGCCCGACTGCATGGTGATCTGGCTGGTTGCTTTAAAA
TAAAGCTGAGAGCATCTGGTTTTCGTTTGATTTACAAGGTTATCGATGACGAGATTGTTATATGGGTGGTCGCTGTAGGT
AAACGGGAAGACGAAAAAGCCTATGAAACGGCCCGTAAGCGGCTTTTATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15507.80 Da        Isoelectric Point: 4.5265

>AT170347 WP_187001384.1 NZ_CP060414:c1164196-1163780 [Neisseria musculi]
MLAYRYILTPDDNGTLLVTFPDIPEAVAVGEDEESAKIEAVDGLICALEGYFEDRREIPLPSENDGSQTVELPALETAKV
LLLNEMLRQNVKKAEMARRLDVHMPQIDRLLDLRHNTKIDFLEKAAGKLGKRLNISFS

Download         Length: 417 bp

>AT170347 NZ_CP077292:18446-18700 [Citrobacter farmeri]
ATGAGCACAATTCAGATCCGCGTTGATGACGAGCTGAAAAAAGAGGCCTATCAGGCTTTTGAAAAACTGAATCTGTCACC
TTCAGACGCACTTCGTCTGTTCCTGCGGTATGTCGCTGAGAACGAAAAACTCCCCTTTGCTGAAGTCTCAGTGATGGTAA
GCGATGATGATGAAGACGCTGATATTCTGGCAGTCGTTCGGGAAAGACTGAAAAATCCGGCCAGACGGATCAGGGTTAAC
GTTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References