Detailed information of TA system TA170346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09812-MazE
• Location: 558762..559348
• Replicon: chromosome
• Accession: NZ_CP060414
• Organism: Neisseria musculi strain NW831

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: H7A79_RS02715
• Protein ID: WP_187000995.1
• Coordinates: 558762..559106 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: H7A79_RS02720
• Protein ID: WP_187001601.1
• Coordinates: 559106..559348 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A79_RS02675	554416..554646	+	231	WP_187000992.1	antitoxin	-
H7A79_RS02680	554646..555065	+	420	WP_187000993.1	type II toxin-antitoxin system VapC family toxin	-
H7A79_RS02685	555224..555403	+	180	WP_187000239.1	hypothetical protein	-
H7A79_RS02690	555390..555956	-	567	WP_187000240.1	hypothetical protein	-
H7A79_RS02695	555934..556392	-	459	WP_187000241.1	hypothetical protein	-
H7A79_RS02700	556444..557208	-	765	Protein_528	N-6 DNA methylase	-
H7A79_RS02705	557272..557670	-	399	WP_187000242.1	phosphoglycerate kinase	-
H7A79_RS02710	558280..558705	+	426	WP_187000994.1	hypothetical protein	-
H7A79_RS02715	558762..559106	-	345	WP_187000995.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
H7A79_RS02720	559106..559348	-	243	WP_187001601.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
H7A79_RS02725	559835..560260	+	426	WP_187000996.1	hypothetical protein	-
H7A79_RS02730	560318..560599	-	282	WP_187000997.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H7A79_RS02735	560590..560874	-	285	WP_187000998.1	ribbon-helix-helix domain-containing protein	-
H7A79_RS02740	561384..562104	-	721	Protein_536	hypothetical protein	-
H7A79_RS02745	562110..562319	-	210	WP_187000245.1	hypothetical protein	-
H7A79_RS02750	562429..563067	+	639	WP_135037386.1	helix-turn-helix domain-containing protein	-
H7A79_RS02755	563133..563375	-	243	WP_187000246.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H7A79_RS02760	563408..563674	-	267	WP_135037392.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• SpoVT-AbrB domain (4-47)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12466.49 Da
• Isoelectric Point: 8.5278

>T170346 WP_187000995.1 NZ_CP060414:c559106-558762 [Neisseria musculi]
MYIPDKGDIIHLRFDPASGKEMKGGHFALVLTPKAFNKAVGLVFACPISQGQASAARGMLSTLLGAGTHTQGNIHCHQLK
SLDWRERKAALKEKVPDYVLQDVLSRIEAILELD

Nucleotide

• Length: 345 bp

>T170346 NZ_CP077291:c4549618-4549343 [Citrobacter farmeri]
ATGAGACAGCAGGTGTTATCCCTACGGAAAAAGCAAAGAAGCACGCTGGAGCAGCTCTTTAAAACTCCCGTACCGCAAGG
TATTAAGTGGGTGGACATTGAATCGCTGATTAAAGCGTTAGGTGGGGAGATCAAAGAGGGGCGCGGTTCACGCTGCAAAT
TTTTGTTAAACAAGAGCATTGCGTGTTTTCATCGGCCTCATCCTTCACCGGATACAGATAAAGGCGCAGTAGAGAGCGTA
CGTGAATGGTTAGTCAGTATAGGGGTTAAACCATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8926.39 Da
• Isoelectric Point: 8.5779

>AT170346 WP_187001601.1 NZ_CP060414:c559348-559106 [Neisseria musculi]
MKLQKWGNSAAVRFPKEIISRLGLEIGDELQTEIQGQTIMIKAAKRPKYKLSDLLAEMPEGAPRVAGWDEMSDVGREVAK

Nucleotide

• Length: 243 bp

>AT170346 NZ_CP077291:c4549346-4548987 [Citrobacter farmeri]
ATGATCAAACTTAAAATGCCAAACGCAATGGAGATCGCCGGACAACCGGCCGTAATCAATTACGTTCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGGTTGTCAGGCTATTGTGATTTTGTGTCAGACAGTATTCAAGGGCTGCAAAAAGAGGGGG
AACTCTCGTTGCGCGAATATCTTGACGACTGTCGTGAAGCGGGCATTGAACCCTACGCTCAGCAGGAAAAGCTTAAAACA
TTTACCTTACGCTATCCGGAGTCCTTCGGAGAACGTCTGAGTTTTGCAGCGGCGCAAGAGCAGGTATCCGTGAATACCTG
GATTATTGACACGCTGAGTGAACGCCTGAAACAGGCATAG