Detailed information of TA system TA170345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 554416..555065
• Replicon: chromosome
• Accession: NZ_CP060414
• Organism: Neisseria musculi strain NW831

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H7A79_RS02680
• Protein ID: WP_187000993.1
• Coordinates: 554646..555065 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H7A79_RS02675
• Protein ID: WP_187000992.1
• Coordinates: 554416..554646 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7A79_RS02650	549899..550207	+	309	WP_187000989.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H7A79_RS02655	550216..550506	+	291	WP_187000990.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H7A79_RS02660	550591..551607	+	1017	WP_187000991.1	site-specific DNA-methyltransferase	-
H7A79_RS02665	551623..552371	+	749	Protein_521	phage Gp37/Gp68 family protein	-
H7A79_RS02670	552368..554255	+	1888	Protein_522	DNA cytosine methyltransferase	-
H7A79_RS02675	554416..554646	+	231	WP_187000992.1	antitoxin	Antitoxin
H7A79_RS02680	554646..555065	+	420	WP_187000993.1	type II toxin-antitoxin system VapC family toxin	Toxin
H7A79_RS02685	555224..555403	+	180	WP_187000239.1	hypothetical protein	-
H7A79_RS02690	555390..555956	-	567	WP_187000240.1	hypothetical protein	-
H7A79_RS02695	555934..556392	-	459	WP_187000241.1	hypothetical protein	-
H7A79_RS02700	556444..557208	-	765	Protein_528	N-6 DNA methylase	-
H7A79_RS02705	557272..557670	-	399	WP_187000242.1	phosphoglycerate kinase	-
H7A79_RS02710	558280..558705	+	426	WP_187000994.1	hypothetical protein	-
H7A79_RS02715	558762..559106	-	345	WP_187000995.1	type II toxin-antitoxin system PemK/MazF family toxin	-
H7A79_RS02720	559106..559348	-	243	WP_187001601.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14917.20 Da
• Isoelectric Point: 5.1532

>T170345 WP_187000993.1 NZ_CP060414:554646-555065 [Neisseria musculi]
MILLDTNVISEPLRPQPQASVTAWLDRQPVEALYLSAITVAELRFGIAILPDGRKKQLLSERLEQAVLPLFGERILDFGI
EAAAAYAQVRAKARAAGYAVAAADGYIAAIARAHDFAVATRDISPFAAAGLSVINPFQE

Nucleotide

• Length: 420 bp

>T170345 NZ_CP077291:c4157176-4156862 [Citrobacter farmeri]
ATGCACCTGATAACACTGAAAGCATTGCGAGATGCTGCTGAAAAATATCCGCAGCATACACCGGAGTTGATCGCGCTGGG
GAATGTCCTCTCTAAGGGTTGCTTTAGAACCCCTGCGGCTTTGAAAGCGGTTTTTCCTTCTCTGGATAATTTTAAATATC
TTGATAAACACTATGTGATCAACATTGGCCGAAATGCGTTACGTGTGGTGGTCTTACTCTTTTTCACCTCGCAAAAATGC
TATATACGACATGTGTTTACACATAAAGAATATGACGCTTTCACCGCAATGCATCGTACCAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8291.44 Da
• Isoelectric Point: 8.9154

>AT170345 WP_187000992.1 NZ_CP060414:554416-554646 [Neisseria musculi]
MPSITVRNLSEETHRALKARAAAAGRSTEAEIRLILDQTANPPQRVRLGSLLSGIGREVGGVDFDIERKPEPETKL

Nucleotide

• Length: 231 bp

>AT170345 NZ_CP077291:c4156865-4156449 [Citrobacter farmeri]
ATGATGGTGATTTCAGAAATCCTGAAAGCAGGTGAAAAGCTGACGGCTGTTGCGCCTTTTTTAGCGGGGATCCATAACGA
AGAACAGTACGCAGATGCGATGCTTTTTATCGATCATCTGTTGCTTAACGATCCTGATAACCCATTGCTGGATCTCGTTT
GCGCCAAAATCACTGCCTGGGAAAAATCAGCGCCGGAATTTGCGGAGTTTAATGCGTTACTGGAAACAATGCCTGCCGGA
GTATCGATCATCCGTGTTTTGATGGATCAACACGGATTGAACATGACAGACCTTCCGGAGATAGGCAGCAAGTCGATGGT
ATCGCGCGTGTTAAATGGGCAGAGAAAGCTAACACTGGAACATGCGAAGAAATTAGCCGCGCGGTTTGGTATATCACCCG
CGCTGTTTATTGATTGA