Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 5779503..5780077 Replicon chromosome
Accession NZ_CP060404
Organism Streptomyces buecherae strain AC541

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H7H31_RS22805 Protein ID WP_187062828.1
Coordinates 5779700..5780077 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag H7H31_RS22800 Protein ID WP_187062827.1
Coordinates 5779503..5779700 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7H31_RS22780 5774568..5775473 + 906 WP_187059855.1 LysR family transcriptional regulator -
H7H31_RS22785 5775666..5776238 + 573 WP_187059856.1 cysteine dioxygenase family protein -
H7H31_RS22790 5776310..5777431 + 1122 WP_187118280.1 putative sulfate exporter family transporter -
H7H31_RS22795 5777782..5779470 + 1689 WP_187118065.1 MFS transporter -
H7H31_RS22800 5779503..5779700 + 198 WP_187062827.1 Arc family DNA-binding protein Antitoxin
H7H31_RS22805 5779700..5780077 + 378 WP_187062828.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H7H31_RS22810 5780223..5782007 + 1785 WP_176161877.1 DEAD/DEAH box helicase -
H7H31_RS22815 5782447..5783085 + 639 WP_176161876.1 helix-turn-helix domain-containing protein -
H7H31_RS22820 5783433..5784017 + 585 WP_197996014.1 hypothetical protein -
H7H31_RS22825 5784231..5784971 - 741 WP_187062830.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(23-117)

Antitoxin

Arc-like DNA binding domain

(4-41)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13850.80 Da        Isoelectric Point: 4.6873

>T170344 WP_187062828.1 NZ_CP060404:5779700-5780077 [Streptomyces buecherae]
MKFLDLPQLLGLAQRLGESEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESLARNHAMVDGNKRLAWYATWVFL
HVNGHPLVEGFDVDEAERFVLNVAQGELDVPKIAELLPRFAASSA

Download         Length: 378 bp

>T170344 NZ_CP077291:c3615802-3615434 [Citrobacter farmeri]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTAATGAAACTGTTATTAAGGAACATATTG
ATGCCGGTATCACTCTGGTCGATGCAGTCAACTTCCTGGTGGATAAGTACAAACTGGCTCGTATCGATCGCAGAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACCGTAACAGATATCCTTCATGCCAGGAAAGCATGCGGATTAATGAACAGTTG
TTCTTATCAGGACGTAAGTAATATTGTTCTTAGCCGATCGCGTCAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7352.26 Da        Isoelectric Point: 5.0631

>AT170344 WP_187062827.1 NZ_CP060404:5779503-5779700 [Streptomyces buecherae]
MAALNLRFTEEELDALRERAEAEGRSMQAFAHDAVMVAINEHSRLYNEAADHVLKVSAELNRRLA

Download         Length: 198 bp

>AT170344 NZ_CP077291:c3616164-3615823 [Citrobacter farmeri]
ATGAAATCTACAGACTCAGAGAACGATTCATTTCTCCAGTGGGGGCTGAATCGTAATGTGACGCCTTGCTTTGGCGCTCG
TCTGGTACAGGGGGGAAACCGGCTGCACTATCTGGTTGACCGGGCCAGCATTACCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACGTTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References