Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 785942..786558 Replicon chromosome
Accession NZ_CP060402
Organism Microbacterium sp. YJN-G

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H7694_RS03670 Protein ID WP_193598189.1
Coordinates 786160..786558 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H7694_RS03665 Protein ID WP_193598188.1
Coordinates 785942..786163 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7694_RS03650 782331..782798 + 468 WP_193598185.1 DUF3817 domain-containing protein -
H7694_RS03655 782795..784381 + 1587 WP_193598186.1 glutamine-hydrolyzing GMP synthase -
H7694_RS03660 784481..785899 + 1419 WP_193598187.1 glycosyltransferase -
H7694_RS03665 785942..786163 + 222 WP_193598188.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
H7694_RS03670 786160..786558 + 399 WP_193598189.1 PIN domain nuclease Toxin
H7694_RS03675 786737..787162 + 426 WP_193598190.1 YciI family protein -
H7694_RS03680 787165..788448 + 1284 WP_193598191.1 RNA polymerase sigma factor -
H7694_RS03685 788573..788845 - 273 WP_193598192.1 GlsB/YeaQ/YmgE family stress response membrane protein -
H7694_RS03690 789030..789932 - 903 WP_193598193.1 Bax inhibitor-1/YccA family protein -
H7694_RS03695 789996..791006 + 1011 WP_193598194.1 glycerophosphodiester phosphodiesterase -
H7694_RS03700 791043..791450 - 408 WP_193598195.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-41)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14377.56 Da        Isoelectric Point: 5.5499

>T170342 WP_193598189.1 NZ_CP060402:786160-786558 [Microbacterium sp. YJN-G]
VILIDTSAWIDYLRAARTEAHFEVRSVLQSDADVRISEPIIMELVAGSRGNEVGIEALVDGLPLLPIEPGLDFRAAGELF
RASRANGHPIRSLVDCLIAAIAMRHGATLLHKDRDFTFLAEISPLKLHSPSA

Download         Length: 399 bp

>T170342 NZ_CP077291:2372114-2372596 [Citrobacter farmeri]
ATGGGAATAAGAGCGCCTGAACCCTTAACCCCCGGACACATTGTTGCTGAATTTTGCTGCTCTGATCCGGGTCTCAATGA
GTGGCTTAGAAAGAAAGCATTAAAAAACCACAGCACCGGCATTTCCCGTGTGTATGTTATTTGTGCCGAAGAGACGAACA
GGGTTATTGGATACTATTGTCTTTCAACCGGCAGCGTTCAACGAAATACGGTCCCAGGCTCCTATCGCCGTAATGCCCCC
GAATCACTTCCCGTAGTGGTACTCGGCAGACTTGCCGTTGACCAGTCCTGTGCAGGAAAAGGACTTGGCGTTGCTCTGCT
CAGAGATGCGATTTTCCGCACGGAAAATATTGCGCTACAGGTCGGCGTGAGAGCATTAATCGTGCATGCGCTTAATGATG
ACGTGAAAAGTTTCTATATGAAATTTGCGTTTGCCCCCTCATCGATCAATCCACTTACCCTGCTCTACCCTATTAAAGTT
TGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8376.41 Da        Isoelectric Point: 4.2931

>AT170342 WP_193598188.1 NZ_CP060402:785942-786163 [Microbacterium sp. YJN-G]
MSRTNIDIDDDLVSEVMQRYSLTTKKDAVNFALRRLVGVPLTKEFLLSMEGSGWDGDLDEMRDDAPREAWARQ

Download         Length: 222 bp

>AT170342 NZ_CP077291:2371845-2372123 [Citrobacter farmeri]
ATGAAACCAGAAGCCAGAGAAGCGCCTATCAACATCCGGGCGAAAACATCCCAACGTGACCTGATAGATATGGCTGCAAG
CCTTGTATCAAAATCACGTACCGACTTCGTACTTGAAGCTGCCTGTCGTGAAGCCCAGGATATTCTGCTTGATCAGCGTT
TGTTCATCCTGGACGATAAACAGTATGACGCTTTTCTTGCGGAACTGGATGCCCCTATCACTCCTGAACGACAGGCACGG
ATCAACGATCTCATGAGTCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References