170338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3779189..3780739 Replicon chromosome
Accession NZ_CP060401
Organism Xenorhabdus nematophila strain SII

Toxin (Protein)


Gene name hipA Uniprot ID N1NQE2
Locus tag H8F46_RS16945 Protein ID WP_010847710.1
Coordinates 3779441..3780739 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID N1NPE2
Locus tag H8F46_RS16940 Protein ID WP_010847709.1
Coordinates 3779189..3779440 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F46_RS16920 3774486..3775769 + 1284 WP_013185552.1 serine hydroxymethyltransferase -
H8F46_RS16925 3775735..3776496 - 762 WP_013183573.1 IS5 family transposase -
H8F46_RS16930 3777192..3778232 + 1041 Protein_3297 IS630 family transposase -
H8F46_RS16935 3778372..3779085 - 714 Protein_3298 IS630 family transposase -
H8F46_RS16940 3779189..3779440 + 252 WP_010847709.1 helix-turn-helix domain-containing protein Antitoxin
H8F46_RS16945 3779441..3780739 + 1299 WP_010847710.1 type II toxin-antitoxin system HipA family toxin Toxin
H8F46_RS16950 3781132..3782412 + 1281 WP_013185547.1 dicarboxylate/amino acid:cation symporter -
H8F46_RS16955 3782567..3783457 - 891 WP_038220625.1 LysR family transcriptional regulator -
H8F46_RS16960 3783586..3784278 + 693 WP_041977848.1 amino acid racemase -
H8F46_RS16965 3784799..3785719 - 921 WP_041977851.1 DUF91 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3777192..3778058 866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48428.67 Da        Isoelectric Point: 7.2017

>T170338 WP_010847710.1 NZ_CP060401:3779441-3780739 [Xenorhabdus nematophila]
MNKLIVALNGLEVGVLFRDKKGAMSFQYTNEWLKEPGTRAISLSLPLSNQKYVGQEVFNFFDNLLPDSREIIARMQARFQ
ITSKHPFDLLASVGRDCVGAIQLYQEGNQIPPIDEVHAEPLDERAIVELLEGYKTTPLGMNNSDNFRISLAGAQEKTALL
WHQGCWQRPYGSTPTSHIFKLPIGRIEHNNIDLHESCENEWLCLKIARTFGLPVANAELAKFGEKTVLIVERFDRRWSCD
NRWLMRLPQEDMCQAMGIAPALKYEADGGPGIADIMTLLLGSRNSITDRETFFKSQILYWLLAAIDGHGKNFSIFIEPDS
SYSMTPLYDILSAYPIFGAKGVAPKKAKMAMALRGKSRQYHWATIQPRHFPSTARQVGFSESMAEKLMNEMGNMAEKVIN
QVANELPPNFPGHISDAIFTGLAKQAGRLCAG

Download         Length: 1299 bp

>T170338 NZ_CP077291:1937537-1937640 [Citrobacter farmeri]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9479.82 Da        Isoelectric Point: 10.9422

>AT170338 WP_010847709.1 NZ_CP060401:3779189-3779440 [Xenorhabdus nematophila]
MKITSPQTLAVAIREQRKKKRLTQKDTADRVGIKQSTVSGFENSPEKSKLETLFKLLSSLGLELQVTERNGSTKSDSRWT
REW

Download         Length: 252 bp

>AT170338 NZ_CP077291:c1937646-1937442 [Citrobacter farmeri]
ACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTCCGCGGCTTACGCGG
CCTGAAAAAAACGGTGATGGTCACTGCCTGAAATGTAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NQE2

Antitoxin

Source ID Structure
AlphaFold DB N1NPE2

References