Detailed information of TA system TA170330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3234580..3236318
• Replicon: chromosome
• Accession: NZ_CP060401
• Organism: Xenorhabdus nematophila strain SII

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: H8F46_RS14315
• Protein ID: WP_041979641.1
• Coordinates: 3235419..3236318 (+)
• Length: 300 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: N1NP62
• Locus tag: H8F46_RS14310
• Protein ID: WP_010847657.1
• Coordinates: 3234580..3235356 (+)
• Length: 259 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F46_RS14285	3229823..3231010	-	1188	WP_038219097.1	multidrug efflux MFS transporter EmrD	-
H8F46_RS14290	3231322..3232068	+	747	WP_038219098.1	ferredoxin--NADP(+) reductase	-
H8F46_RS14295	3232083..3232529	-	447	WP_038219114.1	DUF805 domain-containing protein	-
H8F46_RS14300	3232588..3233208	+	621	WP_038219100.1	DUF1454 family protein	-
H8F46_RS14305	3233297..3234064	+	768	WP_038219101.1	triose-phosphate isomerase	-
H8F46_RS14310	3234580..3235356	+	777	WP_010847657.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
H8F46_RS14315	3235419..3236318	+	900	WP_041979641.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H8F46_RS14320	3236560..3236958	-	399	WP_013183155.1	type II toxin-antitoxin system death-on-curing family toxin	-
H8F46_RS14325	3236955..3237176	-	222	WP_010847654.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H8F46_RS14330	3237435..3237995	-	561	Protein_2783	DUF4102 domain-containing protein	-
H8F46_RS14335	3238323..3239147	-	825	WP_038219103.1	DNA damage-inducible protein D	-
H8F46_RS14340	3239857..3240069	-	213	WP_113935543.1	ogr/Delta-like zinc finger family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (6-250)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (100-250)

Sequences

Toxin

Protein

• Length: 300 a.a.
• Molecular weight: 34215.47 Da
• Isoelectric Point: 5.0397

>T170330 WP_041979641.1 NZ_CP060401:3235419-3236318 [Xenorhabdus nematophila]
MLPVVAQEKMFALKGGTAINLFVREFPRLSVDIDLAYLPLEPRDVALVNVRAALQRIVDNINVQPNVTAILQDNKTDELR
IVISNNNATIKIEISPVARGTLHKPEDRAVVEFVEDEFGYAEISVVSLPDLYGGKICAAMDRQHPRDLFDVKMLLNEEGI
SRDIFIGFLTYALSHKRPINEIMAPNWQSMGEKFSREFEGMTLEQVELAELEAIRFEMLAELQKHLTEKDRHFLLSFKRG
EPDWALFDALSAADLPAIRWKLLNIETLKTKNPDKHQEQLKKLEQVLDQWLKKAELNSQ

Nucleotide

• Length: 900 bp

>T170330 NZ_CP077290:c2652260-2651946 [Enterobacter cancerogenus]
ATGCATTTAATCTCAATGAAGGCTATTTTTGATGCGGTAACTCTCTTTCCGCAGCATAAGCAAGAACTCCTTTTTCTGGG
GAGAATCATTGAAAAGAGCAATTGTCCCACGCCTGATGCACTTAAAAAGCTGTTTCCGACGCTCGACAACTTTAAGTATC
TGGATAAACATTATGTCCTTGATATCGCTAACAACAATCTCAGAGTAGTGGCTCTCATTTTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin

Protein

• Length: 259 a.a.
• Molecular weight: 29804.00 Da
• Isoelectric Point: 9.9742

>AT170330 WP_010847657.1 NZ_CP060401:3234580-3235356 [Xenorhabdus nematophila]
MNSKINWLVNHTTPGSLVLQQWLVENGISHSLTQKYAQNGWLKKLFTGVYYRPDPIKNHIPNWADALQALADQIHLQIHI
SGLTSLTHQGLSHYLPLKSEKVWIGVRNKQSLPKWFKEFPNQNWQYCNNSKLRELSDKDFTIVLVNGKELKASTPELAAY
EAVDSIGKHISFEHTAELFQGLVNLSPRKVQSLLNRSKAVQTNRIFLYLSHYHDHQWVKRLDESQIELGSGKRQVVTQGR
YDERYKITIPESLIPKSQ

Nucleotide

• Length: 777 bp

>AT170330 NZ_CP077290:c2651949-2651530 [Enterobacter cancerogenus]
ATGATGATCGTCGCTGATGCAATGAAAGCCACGCACGCCCTTGTTGCGGCTGTTCCTCTACTGGGTGAACATCCGAATGA
GCAGGATTACAACGATGCGCTTGAGCTGGTTGAGTATCTGCTTATGAATGAGCCTGGCAGCCCGTTGCTCGATATCGTAT
GCGCAAGAATTCGCCATTATGAAGCCAATCAGCCTGAAATCGTCGCATTACGTCAGGAGATGGAATCTGTTCCCGTGGGT
ATCGCCGTCCTAAGAACCCTGATGGATCAGTACAAGCTTACCTTGTCTGATTTTCAGGATGAAATTGGCAGTAAATCAAT
GGTTTCACGGGTGCTTAACGGCCAACGTCAGCTGACGCTGACCCACATTAAAAAGCTGGCAGCCCGATTTGGCGTGTCAC
CTGCGCTGTTTATTGAGTAA

Structures

Antitoxin

• AlphaFold DB: N1NP62