Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3234580..3236318 | Replicon | chromosome |
| Accession | NZ_CP060401 | ||
| Organism | Xenorhabdus nematophila strain SII | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | H8F46_RS14315 | Protein ID | WP_041979641.1 |
| Coordinates | 3235419..3236318 (+) | Length | 300 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | N1NP62 |
| Locus tag | H8F46_RS14310 | Protein ID | WP_010847657.1 |
| Coordinates | 3234580..3235356 (+) | Length | 259 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H8F46_RS14285 | 3229823..3231010 | - | 1188 | WP_038219097.1 | multidrug efflux MFS transporter EmrD | - |
| H8F46_RS14290 | 3231322..3232068 | + | 747 | WP_038219098.1 | ferredoxin--NADP(+) reductase | - |
| H8F46_RS14295 | 3232083..3232529 | - | 447 | WP_038219114.1 | DUF805 domain-containing protein | - |
| H8F46_RS14300 | 3232588..3233208 | + | 621 | WP_038219100.1 | DUF1454 family protein | - |
| H8F46_RS14305 | 3233297..3234064 | + | 768 | WP_038219101.1 | triose-phosphate isomerase | - |
| H8F46_RS14310 | 3234580..3235356 | + | 777 | WP_010847657.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| H8F46_RS14315 | 3235419..3236318 | + | 900 | WP_041979641.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| H8F46_RS14320 | 3236560..3236958 | - | 399 | WP_013183155.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| H8F46_RS14325 | 3236955..3237176 | - | 222 | WP_010847654.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| H8F46_RS14330 | 3237435..3237995 | - | 561 | Protein_2783 | DUF4102 domain-containing protein | - |
| H8F46_RS14335 | 3238323..3239147 | - | 825 | WP_038219103.1 | DNA damage-inducible protein D | - |
| H8F46_RS14340 | 3239857..3240069 | - | 213 | WP_113935543.1 | ogr/Delta-like zinc finger family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 300 a.a. Molecular weight: 34215.47 Da Isoelectric Point: 5.0397
>T170330 WP_041979641.1 NZ_CP060401:3235419-3236318 [Xenorhabdus nematophila]
MLPVVAQEKMFALKGGTAINLFVREFPRLSVDIDLAYLPLEPRDVALVNVRAALQRIVDNINVQPNVTAILQDNKTDELR
IVISNNNATIKIEISPVARGTLHKPEDRAVVEFVEDEFGYAEISVVSLPDLYGGKICAAMDRQHPRDLFDVKMLLNEEGI
SRDIFIGFLTYALSHKRPINEIMAPNWQSMGEKFSREFEGMTLEQVELAELEAIRFEMLAELQKHLTEKDRHFLLSFKRG
EPDWALFDALSAADLPAIRWKLLNIETLKTKNPDKHQEQLKKLEQVLDQWLKKAELNSQ
MLPVVAQEKMFALKGGTAINLFVREFPRLSVDIDLAYLPLEPRDVALVNVRAALQRIVDNINVQPNVTAILQDNKTDELR
IVISNNNATIKIEISPVARGTLHKPEDRAVVEFVEDEFGYAEISVVSLPDLYGGKICAAMDRQHPRDLFDVKMLLNEEGI
SRDIFIGFLTYALSHKRPINEIMAPNWQSMGEKFSREFEGMTLEQVELAELEAIRFEMLAELQKHLTEKDRHFLLSFKRG
EPDWALFDALSAADLPAIRWKLLNIETLKTKNPDKHQEQLKKLEQVLDQWLKKAELNSQ
Download Length: 900 bp
>T170330 NZ_CP077290:c2652260-2651946 [Enterobacter cancerogenus]
ATGCATTTAATCTCAATGAAGGCTATTTTTGATGCGGTAACTCTCTTTCCGCAGCATAAGCAAGAACTCCTTTTTCTGGG
GAGAATCATTGAAAAGAGCAATTGTCCCACGCCTGATGCACTTAAAAAGCTGTTTCCGACGCTCGACAACTTTAAGTATC
TGGATAAACATTATGTCCTTGATATCGCTAACAACAATCTCAGAGTAGTGGCTCTCATTTTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA
ATGCATTTAATCTCAATGAAGGCTATTTTTGATGCGGTAACTCTCTTTCCGCAGCATAAGCAAGAACTCCTTTTTCTGGG
GAGAATCATTGAAAAGAGCAATTGTCCCACGCCTGATGCACTTAAAAAGCTGTTTCCGACGCTCGACAACTTTAAGTATC
TGGATAAACATTATGTCCTTGATATCGCTAACAACAATCTCAGAGTAGTGGCTCTCATTTTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA
Antitoxin
Download Length: 259 a.a. Molecular weight: 29804.00 Da Isoelectric Point: 9.9742
>AT170330 WP_010847657.1 NZ_CP060401:3234580-3235356 [Xenorhabdus nematophila]
MNSKINWLVNHTTPGSLVLQQWLVENGISHSLTQKYAQNGWLKKLFTGVYYRPDPIKNHIPNWADALQALADQIHLQIHI
SGLTSLTHQGLSHYLPLKSEKVWIGVRNKQSLPKWFKEFPNQNWQYCNNSKLRELSDKDFTIVLVNGKELKASTPELAAY
EAVDSIGKHISFEHTAELFQGLVNLSPRKVQSLLNRSKAVQTNRIFLYLSHYHDHQWVKRLDESQIELGSGKRQVVTQGR
YDERYKITIPESLIPKSQ
MNSKINWLVNHTTPGSLVLQQWLVENGISHSLTQKYAQNGWLKKLFTGVYYRPDPIKNHIPNWADALQALADQIHLQIHI
SGLTSLTHQGLSHYLPLKSEKVWIGVRNKQSLPKWFKEFPNQNWQYCNNSKLRELSDKDFTIVLVNGKELKASTPELAAY
EAVDSIGKHISFEHTAELFQGLVNLSPRKVQSLLNRSKAVQTNRIFLYLSHYHDHQWVKRLDESQIELGSGKRQVVTQGR
YDERYKITIPESLIPKSQ
Download Length: 777 bp
>AT170330 NZ_CP077290:c2651949-2651530 [Enterobacter cancerogenus]
ATGATGATCGTCGCTGATGCAATGAAAGCCACGCACGCCCTTGTTGCGGCTGTTCCTCTACTGGGTGAACATCCGAATGA
GCAGGATTACAACGATGCGCTTGAGCTGGTTGAGTATCTGCTTATGAATGAGCCTGGCAGCCCGTTGCTCGATATCGTAT
GCGCAAGAATTCGCCATTATGAAGCCAATCAGCCTGAAATCGTCGCATTACGTCAGGAGATGGAATCTGTTCCCGTGGGT
ATCGCCGTCCTAAGAACCCTGATGGATCAGTACAAGCTTACCTTGTCTGATTTTCAGGATGAAATTGGCAGTAAATCAAT
GGTTTCACGGGTGCTTAACGGCCAACGTCAGCTGACGCTGACCCACATTAAAAAGCTGGCAGCCCGATTTGGCGTGTCAC
CTGCGCTGTTTATTGAGTAA
ATGATGATCGTCGCTGATGCAATGAAAGCCACGCACGCCCTTGTTGCGGCTGTTCCTCTACTGGGTGAACATCCGAATGA
GCAGGATTACAACGATGCGCTTGAGCTGGTTGAGTATCTGCTTATGAATGAGCCTGGCAGCCCGTTGCTCGATATCGTAT
GCGCAAGAATTCGCCATTATGAAGCCAATCAGCCTGAAATCGTCGCATTACGTCAGGAGATGGAATCTGTTCCCGTGGGT
ATCGCCGTCCTAAGAACCCTGATGGATCAGTACAAGCTTACCTTGTCTGATTTTCAGGATGAAATTGGCAGTAAATCAAT
GGTTTCACGGGTGCTTAACGGCCAACGTCAGCTGACGCTGACCCACATTAAAAAGCTGGCAGCCCGATTTGGCGTGTCAC
CTGCGCTGTTTATTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|