Detailed information of TA system TA170325

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1993080..1993497
• Replicon: chromosome
• Accession: NZ_CP060401
• Organism: Xenorhabdus nematophila strain SII

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H8F46_RS08430
• Protein ID: WP_010847386.1
• Coordinates: 1993080..1993253 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N1NP74
• Locus tag: H8F46_RS08435
• Protein ID: WP_010847387.1
• Coordinates: 1993243..1993497 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F46_RS08410	1988421..1989005	+	585	WP_143767639.1	manganese efflux pump MntP	-
H8F46_RS08415	1989115..1989936	-	822	WP_010847383.1	23S rRNA (guanine(745)-N(1))-methyltransferase	-
H8F46_RS08420	1990220..1991548	-	1329	WP_010847384.1	MFS transporter	-
H8F46_RS08425	1991557..1993080	-	1524	WP_038220282.1	signal transduction histidine-protein kinase/phosphatase UhpB	-
H8F46_RS08430	1993080..1993253	-	174	WP_010847386.1	hypothetical protein	Toxin
H8F46_RS08435	1993243..1993497	-	255	WP_010847387.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H8F46_RS08440	1993937..1994317	+	381	WP_119365265.1	transposase	-
H8F46_RS08445	1994324..1994941	-	618	WP_010847389.1	transcriptional regulator UhpA	-
H8F46_RS08450	1995083..1996459	-	1377	WP_010847390.1	hexose-6-phosphate:phosphate antiporter	-
H8F46_RS08455	1997075..1997410	-	336	WP_038220280.1	hypothetical protein	-
H8F46_RS08460	1997796..1998485	+	690	WP_038220279.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-74)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6931.05 Da
• Isoelectric Point: 10.1541

>T170325 WP_010847386.1 NZ_CP060401:c1993253-1993080 [Xenorhabdus nematophila]
MIFNIEFDERAGKEWQKLDNSIREQFKKKLKKLQKNPYIEPARLHGDLACFLRNFSF

Nucleotide

• Length: 174 bp

>T170325 NZ_CP077290:1560833-1561051 [Enterobacter cancerogenus]
ATGTCTGAAAAACCATTAACCAAGATCGATTATTTGATGCGCTTGCGACGTTGTCAGTCACTGGACACGCTTGAACGTGT
TATCGAAAAAAATAAATATGAGCTTTCTGATAACGAACTGGCTGTATTTTACTCAGCAGCGGATCATCGCCTGGCCGAGT
TAACCATGAATAAGCTTTACGACAAAATACCGTCTTCCGTATGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9831.21 Da
• Isoelectric Point: 4.7025

>AT170325 WP_010847387.1 NZ_CP060401:c1993497-1993243 [Xenorhabdus nematophila]
MSTIQIRVDEELKKSAYQAFDKLNLSPSDAMRLFLRYVAEHEKLPFTEVSVMVAEHDEDEDILDVVRDRLKNPAKRIRVN
LDDI

Nucleotide

• Length: 255 bp

>AT170325 NZ_CP077290:1560431-1560805 [Enterobacter cancerogenus]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGTCTTGC
CAATCTTGATGAAAGTAACCATGGGTGGGTTAACGACCCCACCTCGGCCATCAATTTGCAGCTTAATGAGCTGATAGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAATCGGCT
ATTCCGTTGTTTCATCAATGCAAGTCGAGCTAATCCTGTTAGCCTTTCCTGTTAA

Structures

Antitoxin

• AlphaFold DB: N1NP74