Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1620207..1620958 Replicon chromosome
Accession NZ_CP060401
Organism Xenorhabdus nematophila strain SII

Toxin (Protein)


Gene name ataT Uniprot ID N1NQL5
Locus tag H8F46_RS07000 Protein ID WP_010845782.1
Coordinates 1620207..1620695 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID N1NPQ2
Locus tag H8F46_RS07005 Protein ID WP_010845781.1
Coordinates 1620686..1620958 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F46_RS06985 1615209..1616597 - 1389 WP_038218974.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit beta -
H8F46_RS06990 1616608..1618140 - 1533 WP_010845786.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha -
H8F46_RS06995 1619107..1620060 + 954 WP_038218973.1 DUF1471 domain-containing protein -
H8F46_RS07000 1620207..1620695 - 489 WP_010845782.1 GNAT family N-acetyltransferase Toxin
H8F46_RS07005 1620686..1620958 - 273 WP_010845781.1 DUF1778 domain-containing protein Antitoxin
H8F46_RS07010 1621456..1622850 + 1395 WP_038218972.1 basic amino acid/polyamine antiporter -
H8F46_RS07015 1623023..1623784 + 762 WP_038218971.1 IS5 family transposase -
H8F46_RS07020 1624158..1625168 - 1011 WP_119365309.1 IS110 family transposase -
H8F46_RS07025 1625281..1625448 - 168 Protein_1362 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1625257..1625448 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-145)

Antitoxin

Vibrio phage ICP1, Orf50

(5-89)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 18028.89 Da        Isoelectric Point: 9.0545

>T170324 WP_010845782.1 NZ_CP060401:c1620695-1620207 [Xenorhabdus nematophila]
VGISTPEILTVKHNVKDFYCQHETLNEWLSRRALKNNKLGASRTFVICKEGTKDVIGYYCLSAGSINHIESTPSLKRNMP
DAIPVMLLGRLAVDAEYQGKKLGALLLQDAWKRVASTAEQVGISAIIVHAFDESARTFYMRLGFVQSPLESYTLMLPLGK
QN

Download         Length: 489 bp

>T170324 NZ_CP077290:c334969-333650 [Enterobacter cancerogenus]
ATGCCGACATTAGTGACATGGATGAATAACGAACGCGTCGGTGAACTGACGAAATTGCCAACCGGCGCACATACGTACAG
GTATGACAAAACGTGGCTTTCAAGCCCGTACGCCCGACCTTTGTCGTTATCTCTGCCGCTGCAAACCGGTAATATCACCT
CTGATGCCGTTTTTAACTTCTTTGATAACCTCCTGCCGGATAGTCCTGTCGTCAGGGATCGCATCGTGAAGCGCTATCAG
GCGAAATCTAAACAACCTTTTGATTTACTTTCAGAAATAGGTCGCGACAGCGTGGGCGCCGTGACGTTACTGCCGCCAGA
AGAAGCGAGCCTTAATCCGGTCATGGCCTGGGAAACGCTCAGCGAGCAGAAGCTGGAAGCAATCCTCTCGGCCTATAAAT
CCGATATTCCACTGGGGATGATTGATGACGAAAATGATTTTCGCATTTCCGTCGCCGGCGCCCAGGAAAAGACGGCGTTA
TTAAAGAAGGGAGATGACTGGTGCATCCCGAAAGGCACGACGCCAACGACCCATATCATTAAGTTGCCGATCGGCGAAAT
CAGGCAGCCTAACGCTACGCTGGATTTACGCGACAGCGTCGATAACGAATATTTCTGCCTCAAGTTCGCAAACGCACTGG
GTTTTGAGGTGCCGAAAGCGGAAATCATCAACGCGGGCAGGGTGCGCGCGCTTGCCGTGGAACGCTTCGACAGGCGCTGG
AATGCAGACCACACCGTGTTACTGCGGCTGCCTCAGGAAGATATGTGTCAGACATTCGGACTGCCTTCCTCGTTAAAGTA
CGAATCCGACGGTGGCCCCGGCATTGCGCAAATCATGTCATTTTTACTCGGCTCTAGCGCTGCACTGAAAGATCGCCACA
ACTTTATGAAGTTCCAGGTGTTTCAGTGGCTGTTGGGCGCAACCGACGGCCATGCTAAAAATTTCTCGGTATTTATACAG
GCGGGCGGAAGTTATCGGCTGACGCCATTTTATGACATCATCTCGGCATTCCCGGTACTCGGTGGCGCCGGTATTCACAT
CAGCGATTTGAAACTGGCAATGGGCCTGACGGCAACCAGGGGCCGAAAAAATGCCATCGATAAAATTCATCCGCGCCATT
TTATGGCAACTGCAAAAGCGGTGAAGTTCCCGGAGGATCGGATGAGAGAGATTATGCAGTCGTTCGCAGATCACGTCCCG
CTGGCGCTTAATGAGGTTATGGATTCGCTGCCGGAAGGTTTTTGCGACAAGGTGGCGACGTCGATAACGTCCAACGTACT
CCGGTTGCATGCGCGGTTATGTAAAGAGGTTGGAAAATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10497.99 Da        Isoelectric Point: 7.2775

>AT170324 WP_010845781.1 NZ_CP060401:c1620958-1620686 [Xenorhabdus nematophila]
MRTQPKETPINIRAKAFQRELIDHAANLHSKTRTDFILDAACRAAEEAILDQRHFFVNDEKYQAFMQMLEQPLSDNAGFK
KLMGYKAPWE

Download         Length: 273 bp

>AT170324 NZ_CP077290:c335226-334969 [Enterobacter cancerogenus]
ATGAAAGCATCCATGATATACAGTCCGACGCAGCTGGCGAACGCCATGAGGCTGGTCCGCCAAAAAAACAACTGGACCCA
GAGTGAGCTGGCAAAAAAGATAGGCATTAAGCAGGCGACGATTTCCAATTTTGAAAATGCCCCGGACAATACCACGCTGG
CGACGTTTTTTAAGATACTCCAGTCGCTTGAGATGAGCGTGTCTTTGCACGAAGCAGACCATGCGGTTGCCGATAATCCA
CAGGAGCTGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NQL5

Antitoxin

Source ID Structure
AlphaFold DB N1NPQ2

References