Detailed information of TA system TA170323

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 502455..502980
• Replicon: chromosome
• Accession: NZ_CP060401
• Organism: Xenorhabdus nematophila strain SII

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H8F46_RS02460
• Protein ID: WP_038220597.1
• Coordinates: 502455..502739 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N1NTS9
• Locus tag: H8F46_RS02465
• Protein ID: WP_010848882.1
• Coordinates: 502729..502980 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F46_RS02440	497913..498821	-	909	WP_041979535.1	oxygen-dependent coproporphyrinogen oxidase	-
H8F46_RS02445	499085..500041	-	957	WP_119365228.1	IS110 family transposase	-
H8F46_RS02450	500491..501027	+	537	WP_013184731.1	gluconokinase	-
H8F46_RS02455	501027..502364	+	1338	WP_010848884.1	gluconate transporter	-
H8F46_RS02460	502455..502739	-	285	WP_038220597.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H8F46_RS02465	502729..502980	-	252	WP_010848882.1	plasmid stabilization protein	Antitoxin
H8F46_RS02470	503061..503799	-	739	Protein_486	SGNH/GDSL hydrolase family protein	-
H8F46_RS02475	503757..504743	-	987	WP_041977763.1	DUF459 domain-containing protein	-
H8F46_RS02480	504730..505572	-	843	Protein_488	MBOAT family protein	-
H8F46_RS02485	505670..506569	+	900	WP_038219493.1	IS982 family transposase	-
H8F46_RS02490	506585..506930	-	346	Protein_490	MBOAT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	302749..561696	258947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10944.67 Da
• Isoelectric Point: 10.2279

>T170323 WP_038220597.1 NZ_CP060401:c502739-502455 [Xenorhabdus nematophila]
MTYSLKFEKRALKEWEKLGHPIREQFKKKLPERLENPHISSARLSGRNNLYKIKLCSSGYRLVYEVNDHAIVLLVIAVGK
RSGNQVYSVADERE

Nucleotide

• Length: 285 bp

>T170323 NZ_CP077280:142583-143065 [Klebsiella quasipneumoniae]
GTGGGACGTATAACAGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAAAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9140.29 Da
• Isoelectric Point: 3.9282

>AT170323 WP_010848882.1 NZ_CP060401:c502980-502729 [Xenorhabdus nematophila]
MSYQILTTIAASITDLKRNPMGTVADGEGGAVAILNRNEPAFYCVPPELYAYYLELAEDAELNHIADERMKSAEFVSVDL
NDL

Nucleotide

• Length: 252 bp

>AT170323 NZ_CP077280:142329-142595 [Klebsiella quasipneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCAGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGACCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: N1NTS9