Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3237908..3238551 Replicon chromosome
Accession NZ_CP060398
Organism Synechococcus sp. CBW1002

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F24_RS15970 Protein ID WP_197170223.1
Coordinates 3237908..3238306 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F24_RS15975 Protein ID WP_197170224.1
Coordinates 3238315..3238551 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F24_RS15930 3234025..3234261 + 237 WP_197172449.1 nucleotidyltransferase domain-containing protein -
H8F24_RS15935 3234261..3234593 + 333 WP_197155697.1 DUF86 domain-containing protein -
H8F24_RS15940 3235081..3235467 - 387 WP_197170218.1 VOC family protein -
H8F24_RS15945 3235458..3235724 - 267 WP_197170219.1 CDGSH iron-sulfur domain-containing protein -
H8F24_RS15950 3236014..3236673 - 660 WP_197170220.1 hypothetical protein -
H8F24_RS15955 3236640..3237245 - 606 WP_197170221.1 hypothetical protein -
H8F24_RS15960 3237274..3237438 + 165 WP_197155705.1 hypothetical protein -
H8F24_RS15965 3237515..3237829 + 315 WP_197170222.1 hypothetical protein -
H8F24_RS15970 3237908..3238306 - 399 WP_197170223.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F24_RS15975 3238315..3238551 - 237 WP_197170224.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H8F24_RS15980 3238651..3238818 - 168 WP_197159372.1 hypothetical protein -
H8F24_RS15985 3238861..3239046 + 186 WP_197172576.1 hypothetical protein -
H8F24_RS15990 3239133..3239546 + 414 WP_197159277.1 hypothetical protein -
H8F24_RS15995 3239693..3239959 + 267 WP_197155712.1 ribbon-helix-helix protein, CopG family -
H8F24_RS16000 3239959..3240387 + 429 WP_197170225.1 PIN domain-containing protein -
H8F24_RS16005 3240512..3240706 + 195 WP_197155716.1 hypothetical protein -
H8F24_RS16010 3240961..3241128 + 168 WP_197155718.1 hypothetical protein -
H8F24_RS16015 3241170..3241553 - 384 WP_197172452.1 type II toxin-antitoxin system VapC family toxin -
H8F24_RS16020 3241556..3241780 - 225 WP_197155720.1 hypothetical protein -
H8F24_RS16025 3242055..3242567 + 513 WP_197170226.1 hypothetical protein -
H8F24_RS16030 3242557..3242892 - 336 WP_197170227.1 hypothetical protein -
H8F24_RS16035 3242863..3243270 + 408 WP_197170228.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14714.96 Da        Isoelectric Point: 7.3222

>T170317 WP_197170223.1 NZ_CP060398:c3238306-3237908 [Synechococcus sp. CBW1002]
MLRYLLDTNICIYVIKQRPASLLERFNENAALMGISAITLAELLHGAEKSSQPRRSLAVVEDFCSRLDVLSYGAKAAQHY
GLIRASLERRGLPIGVNDLHIAAHARSEGLTLVSNNLREFERVDGLLLDNWV

Download         Length: 399 bp

>T170317 NZ_CP077279:484899-485183 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCGACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8948.10 Da        Isoelectric Point: 5.0773

>AT170317 WP_197170224.1 NZ_CP060398:c3238551-3238315 [Synechococcus sp. CBW1002]
VAAVTRLFLSNRSQAVRIPAHLRLPDSVKDVEVRACGEERIISPLGRRWDTFFQDALPVPDDFLQERATQDQPEREAF

Download         Length: 237 bp

>AT170317 NZ_CP077279:484667-484909 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References