Detailed information of TA system TA170314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1497078..1497603
• Replicon: chromosome
• Accession: NZ_CP060398
• Organism: Synechococcus sp. CBW1002

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: H8F24_RS07085
• Protein ID: WP_197157419.1
• Coordinates: 1497078..1497359 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H8F24_RS07090
• Protein ID: WP_197157421.1
• Coordinates: 1497349..1497603 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F24_RS07050	1493296..1493898	-	603	Protein_1389	IS630 family transposase	-
H8F24_RS07055	1494256..1494501	+	246	WP_197157408.1	hypothetical protein	-
H8F24_RS07060	1494559..1495242	+	684	WP_197157410.1	cupin domain-containing protein	-
H8F24_RS07065	1495252..1495671	-	420	WP_197157412.1	nuclear transport factor 2 family protein	-
H8F24_RS07070	1495718..1496134	-	417	WP_197157413.1	hypothetical protein	-
H8F24_RS07075	1496203..1496367	-	165	WP_197157415.1	hypothetical protein	-
H8F24_RS07080	1496481..1497059	-	579	WP_197171562.1	hypothetical protein	-
H8F24_RS07085	1497078..1497359	-	282	WP_197157419.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H8F24_RS07090	1497349..1497603	-	255	WP_197157421.1	hypothetical protein	Antitoxin
H8F24_RS07095	1498203..1500530	-	2328	WP_197172087.1	DEAD/DEAH box helicase	-
H8F24_RS07100	1500601..1500948	-	348	WP_197157423.1	type II toxin-antitoxin system PemK/MazF family toxin	-
H8F24_RS07105	1500948..1501265	-	318	WP_197157425.1	ribbon-helix-helix protein, CopG family	-
H8F24_RS07110	1501342..1501623	-	282	WP_197171564.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H8F24_RS07115	1501613..1501867	-	255	WP_197157429.1	plasmid stabilization protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1493296..1493961	665

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11032.82 Da
• Isoelectric Point: 10.9300

>T170314 WP_197157419.1 NZ_CP060398:c1497359-1497078 [Synechococcus sp. CBW1002]
MPFELAFHPEDLREWRQLSAGIREQFKKKLAERLVVPRIPASKLRDSSDRYKIKLRSAGFRLVYEVRDHEVLVLVVAVGK
RERNAVYRQADQR

Nucleotide

• Length: 282 bp

>T170314 NZ_CP077270:1664284-1664490 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9122.43 Da
• Isoelectric Point: 4.4341

>AT170314 WP_197157421.1 NZ_CP060398:c1497603-1497349 [Synechococcus sp. CBW1002]
MVHRVLAETAVSISEHKKNPMATVAAGEGMAVAVLNRNEPAFYCVPARAYEELMDLVDDLELGRLADARLTDGQEPVRVS
LDAL

Nucleotide

• Length: 255 bp

>AT170314 NZ_CP077270:1663979-1664272 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG