Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 1212229..1212815 Replicon chromosome
Accession NZ_CP060398
Organism Synechococcus sp. CBW1002

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H8F24_RS05790 Protein ID WP_197157705.1
Coordinates 1212558..1212815 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H8F24_RS05785 Protein ID WP_197171362.1
Coordinates 1212229..1212564 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F24_RS05755 1207864..1208061 - 198 WP_197171357.1 hypothetical protein -
H8F24_RS05760 1208510..1210030 - 1521 WP_197171358.1 DUF1254 domain-containing protein -
H8F24_RS05765 1210075..1210383 - 309 Protein_1134 DUF1214 domain-containing protein -
H8F24_RS05770 1210400..1211570 - 1171 Protein_1135 IS3 family transposase -
H8F24_RS05775 1211618..1211917 + 300 WP_197171360.1 transposase -
H8F24_RS05780 1211905..1212174 - 270 WP_197171369.1 hypothetical protein -
H8F24_RS05785 1212229..1212564 - 336 WP_197171362.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
H8F24_RS05790 1212558..1212815 - 258 WP_197157705.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
H8F24_RS05795 1212951..1213259 - 309 WP_197157703.1 putative addiction module antidote protein -
H8F24_RS05800 1213269..1213559 - 291 WP_197171363.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8F24_RS05805 1213694..1214864 + 1171 Protein_1142 IS3 family transposase -
H8F24_RS05810 1215070..1216584 + 1515 WP_197154224.1 IS66 family transposase -
H8F24_RS05815 1216902..1217807 + 906 WP_197171365.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(7-109)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9090.37 Da        Isoelectric Point: 4.3219

>T170311 WP_197157705.1 NZ_CP060398:c1212815-1212558 [Synechococcus sp. CBW1002]
VLGVVVVRAKLVKIGNSRGIRLAKPLLEVAGLADEVEIEAAPGVLTIRPSAHPRAGWAEAASSLEPEGLLDEMSATQFDD
EEWSW

Download         Length: 258 bp

>T170311 NZ_CP077265:2621102-2621320 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12353.24 Da        Isoelectric Point: 8.5596

>AT170311 WP_197171362.1 NZ_CP060398:c1212564-1212229 [Synechococcus sp. CBW1002]
MVTEEHVSRGDIFLVALNPTRGSEIRKTRPCAVVSPDELNAHLRTFIVAPLTTGGHPYPFRVRCRFDGKDGHVVADQLRA
VDRDRLVKRLGSLSETTLNELLSVLQAMFAV

Download         Length: 336 bp

>AT170311 NZ_CP077265:2620701-2621075 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGACGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References