Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2912019..2912710 Replicon chromosome
Accession NZ_CP060397
Organism Synechococcus sp. CBW1004

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F25_RS13765 Protein ID WP_197210901.1
Coordinates 2912019..2912447 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F25_RS13770 Protein ID WP_197210902.1
Coordinates 2912444..2912710 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F25_RS13750 2908806..2909669 - 864 WP_197210898.1 isocitrate lyase/PEP mutase family protein -
H8F25_RS13755 2909666..2911480 - 1815 WP_197210899.1 AMP-binding protein -
H8F25_RS13760 2911574..2911810 - 237 WP_197210900.1 hypothetical protein -
H8F25_RS13765 2912019..2912447 - 429 WP_197210901.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F25_RS13770 2912444..2912710 - 267 WP_197210902.1 hypothetical protein Antitoxin
H8F25_RS13775 2912938..2913588 + 651 WP_197213889.1 imidazoleglycerol-phosphate dehydratase HisB -
H8F25_RS13780 2913611..2913775 - 165 WP_197210903.1 Nif11-like leader peptide family natural product precursor -
H8F25_RS13785 2913899..2915356 + 1458 WP_197210904.1 peptidoglycan-binding protein -
H8F25_RS13790 2915601..2917133 + 1533 WP_197210905.1 carotenoid oxygenase family protein -
H8F25_RS13795 2917176..2917577 - 402 WP_197210906.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15527.05 Da        Isoelectric Point: 5.7653

>T170309 WP_197210901.1 NZ_CP060397:c2912447-2912019 [Synechococcus sp. CBW1004]
MIVVDANLLVYALHADMPKHAAARSWLEQCLSGEEPLALCWVVILAVMRICTNARLFPNALTAHQAIEVAQAWLDHPTVL
LLEPGPRHWEILSEVLDQAGTAGNLTMDAHLAALALEHGGSVHSCDADFRRFPGLRLINPLV

Download         Length: 429 bp

>T170309 NZ_CP077265:c1052390-1052094 [Klebsiella aerogenes]
ATGCAGAATCACATAGGTAGCTTTCGTGATGTATGGTTGGAAGAGTTTTTTTTGCACTCGGCACCACATGAAAAAATTCC
TCCAGACATACATACCACGCTAGCTCGCAAACTCGATATCATCAATGCCGCCGTTACCTATCTGGATTTACGCTCGCCAC
CTGGTAATAGATATGAAGAGCTAAACGGCAAATTGGAAGGTTATTCGTCAATTAGAATTAACCAGCAGTACCGCTTAATA
TTTAAGTGGGTGGATGGAAAAGCGGAAGACCTTTACCTGGATCCGCACAAGTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.39 Da        Isoelectric Point: 5.7879

>AT170309 WP_197210902.1 NZ_CP060397:c2912710-2912444 [Synechococcus sp. CBW1004]
MRTTLTIDDGLLRQLRQKALDSGKTFKQVVNETLRAGLQQPVEAARHRYVCPTFSMGQPQWPVDLDKALTLAAELEDQEI
VTQLMQGQ

Download         Length: 267 bp

>AT170309 NZ_CP077265:c1052036-1051701 [Klebsiella aerogenes]
ATGAAACAGGCAACCAGAAAACCAACTACCGTAGGTGACATCCTGCAGTTTGAATACCTGGAGCCGCTAGATTTAAAAAT
CAACGAACTTGCGGAAATGATACATGTGCATCGTAATAGTGTAAGTGCATTAGTTAACAACAACCGCAAACTAACTACTG
ACATGGCATTTCGCCTGTCTAAAGCCTTCAATACCACCGTTGATTTCTGGCTTAACCTTCAGGCTGCTGTAGATTTGTGG
GAGGTGGAGAATGACACCCGCGCGCAGGAAGAGTTTAGCCGCATTGTTCCTGCCTCGAAATTTATCGCCAGCAAAGCTGA
TAAGAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References