Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2798167..2798606 Replicon chromosome
Accession NZ_CP060397
Organism Synechococcus sp. CBW1004

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H8F25_RS13305 Protein ID WP_197210820.1
Coordinates 2798382..2798606 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H8F25_RS13300 Protein ID WP_197210819.1
Coordinates 2798167..2798379 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F25_RS13275 2793490..2796843 + 3354 WP_197210816.1 type I restriction-modification system endonuclease -
H8F25_RS13280 2796914..2797027 + 114 Protein_2618 Uma2 family endonuclease -
H8F25_RS13285 2797008..2797217 + 210 WP_197210817.1 HigA family addiction module antidote protein -
H8F25_RS13290 2797255..2797515 + 261 WP_197210818.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
H8F25_RS13295 2797539..2797913 + 375 WP_197213864.1 type II toxin-antitoxin system VapC family toxin -
H8F25_RS13300 2798167..2798379 + 213 WP_197210819.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H8F25_RS13305 2798382..2798606 + 225 WP_197210820.1 type II toxin-antitoxin system HicA family toxin Toxin
H8F25_RS13310 2798758..2800278 + 1521 WP_197210821.1 N-6 DNA methylase -
H8F25_RS13315 2800275..2800742 + 468 WP_197210822.1 hypothetical protein -
H8F25_RS13320 2800837..2802378 - 1542 WP_197210823.1 IS5 family transposase -
H8F25_RS13325 2802418..2802918 + 501 WP_197210824.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8297.59 Da        Isoelectric Point: 11.6533

>T170308 WP_197210820.1 NZ_CP060397:2798382-2798606 [Synechococcus sp. CBW1004]
VGSTPVLKPSEVVDILRTLGFELVRQRGSHLQFRDARGRGTTVPAHQGRDIAPPLLRQIAKDIGMTVEEFLRHR

Download         Length: 225 bp

>T170308 NZ_CP077265:682912-683015 [Klebsiella aerogenes]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7463.43 Da        Isoelectric Point: 3.9197

>AT170308 WP_197210819.1 NZ_CP060397:2798167-2798379 [Synechococcus sp. CBW1004]
MRTYSAVIERCSETGLLVGHVPGFPGAHSQGATLDELQANLQEVIAMLLEDGEPNLESDFVGLQQIVVPA

Download         Length: 213 bp

>AT170308 NZ_CP077265:c683023-682877 [Klebsiella aerogenes]
TAATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTGACTGTGACAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References