Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2779352..2779935 Replicon chromosome
Accession NZ_CP060397
Organism Synechococcus sp. CBW1004

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H8F25_RS13185 Protein ID WP_197210803.1
Coordinates 2779352..2779606 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H8F25_RS13190 Protein ID WP_197210804.1
Coordinates 2779603..2779935 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F25_RS13175 2776187..2777737 - 1551 WP_197210801.1 IS5 family transposase -
H8F25_RS13180 2777914..2778897 + 984 WP_197210802.1 IS5 family transposase -
H8F25_RS13185 2779352..2779606 + 255 WP_197210803.1 type II toxin-antitoxin system HicA family toxin Toxin
H8F25_RS13190 2779603..2779935 + 333 WP_197210804.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H8F25_RS13195 2781575..2781781 - 207 Protein_2601 ATP-dependent helicase -
H8F25_RS13200 2781824..2783120 + 1297 Protein_2602 chloride channel protein -
H8F25_RS13205 2783169..2784128 - 960 WP_197210805.1 substrate-binding domain-containing protein -
H8F25_RS13210 2784213..2784587 - 375 WP_197210806.1 hypothetical protein -
H8F25_RS13215 2784714..2784923 - 210 WP_197210807.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9467.79 Da        Isoelectric Point: 10.7342

>T170307 WP_197210803.1 NZ_CP060397:2779352-2779606 [Synechococcus sp. CBW1004]
MKRKNQRTLELIFSRPASGSLPWRDIEALFQELGGDVSERAGSRVAVVLFGEVRVFHRPHPSPDTDKGAIASIRKWFQEH
GVTP

Download         Length: 255 bp

>T170307 NZ_CP077264:c4441995-4441696 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATCCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12461.02 Da        Isoelectric Point: 4.9717

>AT170307 WP_197210804.1 NZ_CP060397:2779603-2779935 [Synechococcus sp. CBW1004]
MNLMNVDGYHAKIDYVEETDQFRGEILGLSGGADFYGASPEELRREFKKSLDVFLEVCKEQGIEPRRHYSGKFNLRIPPE
LHEKLAMTAEAQGKSLNSLAQEALQRSVSE

Download         Length: 333 bp

>AT170307 NZ_CP077264:c4441685-4441320 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCATTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTGGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References