Detailed information of TA system TA170306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2579734..2580416
• Replicon: chromosome
• Accession: NZ_CP060397
• Organism: Synechococcus sp. CBW1004

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H8F25_RS12285
• Protein ID: WP_197213802.1
• Coordinates: 2579734..2580129 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H8F25_RS12290
• Protein ID: WP_197210662.1
• Coordinates: 2580147..2580416 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F25_RS12270	2575570..2576751	+	1182	WP_197210659.1	hypothetical protein	-
H8F25_RS12275	2576834..2577952	-	1119	WP_197210660.1	glycosyltransferase	-
H8F25_RS12280	2578447..2579631	-	1185	WP_197210661.1	NAD(P)H-quinone oxidoreductase subunit H	-
H8F25_RS12285	2579734..2580129	-	396	WP_197213802.1	type II toxin-antitoxin system VapC family toxin	Toxin
H8F25_RS12290	2580147..2580416	-	270	WP_197210662.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
H8F25_RS12295	2580531..2581463	+	933	WP_197210663.1	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	-
H8F25_RS12300	2581625..2582176	+	552	WP_197210664.1	DUF456 family protein	-
H8F25_RS12305	2582196..2583134	-	939	WP_197210665.1	hypothetical protein	-
H8F25_RS12310	2583159..2584301	-	1143	WP_197210666.1	cysteine desulfurase	-
H8F25_RS12315	2584392..2584976	+	585	WP_197213804.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-88)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14274.58 Da
• Isoelectric Point: 4.6983

>T170306 WP_197213802.1 NZ_CP060397:c2580129-2579734 [Synechococcus sp. CBW1004]
MVVDTSALMAVLLQESDAEVLLDAAVRASALYLSTATRLELSLVAESVRHAVKPSEIEQLLLSLRVELVPLDKEQMHWAL
QGWRIYGKGRHAASLNLGDCFCYGLAKALQVPLLFKGEDFAATDLEPALAP

Nucleotide

• Length: 396 bp

>T170306 NZ_CP077264:4201316-4201726 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGGGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9820.15 Da
• Isoelectric Point: 6.9534

>AT170306 WP_197210662.1 NZ_CP060397:c2580416-2580147 [Synechococcus sp. CBW1004]
MGMNIKDPEVHAMARELAARRSTTVTDAVRQALRAELERCPSTEPPSAIEARKAAIRAICARVSARNEWQGLSSKELQDA
LYDEDGLPK

Nucleotide

• Length: 270 bp

>AT170306 NZ_CP077264:4201069-4201335 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA