Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1986446..1987026 Replicon chromosome
Accession NZ_CP060397
Organism Synechococcus sp. CBW1004

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F25_RS09550 Protein ID WP_197213674.1
Coordinates 1986664..1987026 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F25_RS09545 Protein ID WP_197213676.1
Coordinates 1986446..1986667 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F25_RS09520 1981577..1982629 + 1053 WP_197213672.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
H8F25_RS09525 1982586..1983431 - 846 WP_197213673.1 sugar phosphate isomerase/epimerase -
H8F25_RS09530 1983431..1983655 - 225 WP_197214056.1 hypothetical protein -
H8F25_RS09535 1983883..1984368 + 486 WP_197210217.1 DNA starvation/stationary phase protection protein -
H8F25_RS09540 1984512..1986155 + 1644 Protein_1883 CTP synthase -
H8F25_RS09545 1986446..1986667 + 222 WP_197213676.1 ribbon-helix-helix domain-containing protein Antitoxin
H8F25_RS09550 1986664..1987026 + 363 WP_197213674.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F25_RS09555 1987483..1989510 - 2028 WP_197210218.1 alkaline phosphatase family protein -
H8F25_RS09560 1989435..1990118 - 684 WP_197210219.1 hypothetical protein -
H8F25_RS09565 1990509..1991372 + 864 WP_197210220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13496.75 Da        Isoelectric Point: 5.7160

>T170303 WP_197213674.1 NZ_CP060397:1986664-1987026 [Synechococcus sp. CBW1004]
MMLLLDTNILIDVLRGEAVALAWLEQQRQPRISVITWIEVLVGCRAGESSTVEAWLETFPRLPLDDAIAAETVRLRQRHG
LKVPDAIILATARCGTLTLATRNRRDFPIQLGDVLHPYEL

Download         Length: 363 bp

>T170303 NZ_CP077264:c2673606-2673319 [Enterobacter hormaechei]
ATGCCTATAGAGTATGAGTGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGCGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8514.65 Da        Isoelectric Point: 9.9794

>AT170303 WP_197213676.1 NZ_CP060397:1986446-1986667 [Synechococcus sp. CBW1004]
VRTIVDLPDAERAQLDALCRQRGVSRAEALRQALRLWLRQQTPSHHAVFGLWRDRPAGSLELQQALREEWSER

Download         Length: 222 bp

>AT170303 NZ_CP077264:c2673332-2673030 [Enterobacter hormaechei]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGCGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References