Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3251041..3251684 Replicon chromosome
Accession NZ_CP060396
Organism Synechococcus sp. CBW1006

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F26_RS16025 Protein ID WP_197155708.1
Coordinates 3251041..3251439 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F26_RS16030 Protein ID WP_197155710.1
Coordinates 3251448..3251684 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F26_RS15990 3246122..3246454 + 333 WP_197155697.1 DUF86 domain-containing protein -
H8F26_RS15995 3246942..3247328 - 387 WP_197155699.1 VOC family protein -
H8F26_RS16000 3247291..3247569 - 279 WP_197155701.1 CDGSH iron-sulfur domain-containing protein -
H8F26_RS16005 3247877..3248899 - 1023 WP_197155703.1 hypothetical protein -
H8F26_RS16010 3249116..3250286 - 1171 Protein_3148 IS3 family transposase -
H8F26_RS16015 3250407..3250571 + 165 WP_197155705.1 hypothetical protein -
H8F26_RS16020 3250648..3250962 + 315 WP_197155707.1 hypothetical protein -
H8F26_RS16025 3251041..3251439 - 399 WP_197155708.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F26_RS16030 3251448..3251684 - 237 WP_197155710.1 antitoxin Antitoxin
H8F26_RS16035 3251784..3251951 - 168 WP_197159372.1 hypothetical protein -
H8F26_RS16040 3251994..3252179 + 186 WP_197159373.1 hypothetical protein -
H8F26_RS16045 3252266..3252679 + 414 WP_197159277.1 hypothetical protein -
H8F26_RS16050 3252826..3253092 + 267 WP_197155712.1 ribbon-helix-helix protein, CopG family -
H8F26_RS16055 3253092..3253520 + 429 WP_197155714.1 PIN domain-containing protein -
H8F26_RS16060 3253645..3253839 + 195 WP_197155716.1 hypothetical protein -
H8F26_RS16065 3254094..3254261 + 168 WP_197155718.1 hypothetical protein -
H8F26_RS16070 3254303..3254686 - 384 WP_197159278.1 type II toxin-antitoxin system VapC family toxin -
H8F26_RS16075 3254689..3254913 - 225 WP_197155720.1 hypothetical protein -
H8F26_RS16080 3255188..3255700 + 513 WP_197155721.1 hypothetical protein -
H8F26_RS16085 3255996..3256163 + 168 WP_197155723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14694.88 Da        Isoelectric Point: 7.2436

>T170301 WP_197155708.1 NZ_CP060396:c3251439-3251041 [Synechococcus sp. CBW1006]
MLRYLLDTNICIYVIKQRPASLLERFNENAAQMGISAITLAELLHGAEKSSQPRRSLAVVEDFCSRLDVLSYGAKAAQHY
GLIRASLERRGLAIGVNDLHIAAQARSEGLTLVSNNLREFERVDGLLLDNWV

Download         Length: 399 bp

>T170301 NZ_CP077264:2091905-2092216 [Enterobacter hormaechei]
ATGCACATAGTCTCAAGAGCGCCTTTCGACACAGCGGCCAGACATTATCCCAATCAAGCACAAGCCCTGGACGATCTTTA
CCGGGTACTAAAAAAGGAACACTACCCCTCACCAGACGAGATGCGAAAGCGCTTTCCTAGCCTGGACCGGATGAAATACC
GGGAAAAATGGTGGGTCATTGATGTGGGTGGCGGGCATCTAAGAGTGATGTTTTTTGCTGATTTTGAGCGTGGAAAGATC
TTCATCAAACACATCAGCACTCACGCAGACTATGACAAGCTCACGGACTACTACCGGAGAACGAAAGAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8920.08 Da        Isoelectric Point: 5.0773

>AT170301 WP_197155710.1 NZ_CP060396:c3251684-3251448 [Synechococcus sp. CBW1006]
VAAVTKLFLSNRSQAVRIPAHLRLPDSVKDVEVRACGEERIISPLGRRWDTFFQDALPVPDDFLQERATQDQPEREAF

Download         Length: 237 bp

>AT170301 NZ_CP077264:2092213-2092632 [Enterobacter hormaechei]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGCTCTGACAAACGAGCTCCCTTTCCTGGGTTCAAGCCCGTCGCGGCA
AGACTACGAGGATGCGCTGGCGCTGGTAGAGTATCTTATCGAGCACGACCCCGATAACCCGCTGGTAGATATGCTCACTG
CCAAAATCGATAAGTATGAAAACGCGTCCCCGGAGTTTGCAGAATTTAACGCGCGTATTGCCAGCATTCCGTCAGGCGTT
GCGTTACTGCGAACGCTAATGGATCAGTACCAGCTCACTCAGAGTGATTTCGAGAACGAGATTGGTAAGAAGTCTCTGGT
AAGTCGGATCCTTAACGGACAGCGCACGTTAACGCTAGATCATATGCGAGCGCTGGCGAAGCGTTTCGGTTTGCCGGTGA
GCGCATTTGTGGGGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References