Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3209302..3210074 Replicon chromosome
Accession NZ_CP060396
Organism Synechococcus sp. CBW1006

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag H8F26_RS15745 Protein ID WP_197155596.1
Coordinates 3209302..3209802 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag H8F26_RS15750 Protein ID WP_197155598.1
Coordinates 3209802..3210074 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F26_RS15710 3205899..3206174 + 276 WP_197159271.1 hypothetical protein -
H8F26_RS15715 3206224..3206748 - 525 WP_197155585.1 dCTP deaminase -
H8F26_RS15720 3207118..3207207 - 90 WP_197155587.1 hypothetical protein -
H8F26_RS15725 3207505..3207741 - 237 WP_197155589.1 hypothetical protein -
H8F26_RS15730 3207738..3207947 - 210 WP_197155591.1 addiction module protein -
H8F26_RS15735 3208394..3208729 - 336 WP_197155593.1 helix-turn-helix domain-containing protein -
H8F26_RS15740 3208722..3208988 - 267 WP_197155595.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8F26_RS15745 3209302..3209802 - 501 WP_197155596.1 GNAT family N-acetyltransferase Toxin
H8F26_RS15750 3209802..3210074 - 273 WP_197155598.1 DUF1778 domain-containing protein Antitoxin
H8F26_RS15755 3210261..3210413 + 153 WP_197155600.1 hypothetical protein -
H8F26_RS15760 3210410..3211039 + 630 WP_197155608.1 Fic family protein -
H8F26_RS15765 3211252..3211461 - 210 WP_197155610.1 addiction module protein -
H8F26_RS15770 3211740..3211985 - 246 WP_197155612.1 type II toxin-antitoxin system HicA family toxin -
H8F26_RS15775 3211982..3212188 - 207 WP_197159272.1 2-oxoisovalerate dehydrogenase -
H8F26_RS15780 3212475..3212822 + 348 WP_197155614.1 nucleotidyltransferase domain-containing protein -
H8F26_RS15785 3212834..3213097 + 264 WP_197155616.1 HEPN domain-containing protein -
H8F26_RS15790 3213109..3213495 + 387 WP_197155618.1 hypothetical protein -
H8F26_RS15795 3213546..3214487 + 942 WP_197155620.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-83)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 17446.95 Da        Isoelectric Point: 7.3535

>T170298 WP_197155596.1 NZ_CP060396:c3209802-3209302 [Synechococcus sp. CBW1006]
MELLVPQPLASHHGTAGFDCGDTSLDHWLRQRALPNQQSGATRTFVVCDGDGTVKAYGALASGAVAVASAPGSFPRNRPD
PIPVVLLARLAVCRGVQGRGIARALLADAFERVLQASERIGVRGIVVHAASADARNFYLHMGFDPSPIDPDTLLIRLSDV
AATLGL

Download         Length: 501 bp

>T170298 NZ_CP077264:361393-361746 [Enterobacter hormaechei]
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCGACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGGGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGGGGTTCCCATTACAGCA
ACATGAAAGAGCTGCGTATTCAGAGTCGGGGCGATCCGATAAGGGCGTTTTTCTCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10161.50 Da        Isoelectric Point: 11.8010

>AT170298 WP_197155598.1 NZ_CP060396:c3210074-3209802 [Synechococcus sp. CBW1006]
VAATPRLSWNLRVSPDDQALIDRAVRASGLTRTDFVLQAARTAARELLVQQSWQSVSSEHFDQLLRLLDAPPGPSDRLQR
TMTAPRPWQR

Download         Length: 273 bp

>AT170298 NZ_CP077264:361751-362053 [Enterobacter hormaechei]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCCACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAAGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACT
GGCGGTAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References