Detailed information of TA system TA170297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 3186713..3187272
• Replicon: chromosome
• Accession: NZ_CP060396
• Organism: Synechococcus sp. CBW1006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H8F26_RS15590
• Protein ID: WP_197155545.1
• Coordinates: 3186713..3187057 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H8F26_RS15595
• Protein ID: WP_197155547.1
• Coordinates: 3187054..3187272 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F26_RS15560	3182289..3183962	+	1674	WP_197155535.1	YdiU family protein	-
H8F26_RS15565	3184508..3185095	+	588	WP_197155537.1	AAA family ATPase	-
H8F26_RS15570	3185133..3185687	+	555	WP_197155539.1	hypothetical protein	-
H8F26_RS15575	3185706..3186005	-	300	WP_197155541.1	DUF86 domain-containing protein	-
H8F26_RS15580	3186046..3186342	-	297	WP_197155543.1	nucleotidyltransferase family protein	-
H8F26_RS15585	3186385..3186720	-	336	WP_197159268.1	DUF3427 domain-containing protein	-
H8F26_RS15590	3186713..3187057	-	345	WP_197155545.1	DUF5615 family PIN-like protein	Toxin
H8F26_RS15595	3187054..3187272	-	219	WP_197155547.1	DUF433 domain-containing protein	Antitoxin
H8F26_RS15600	3187301..3187846	-	546	Protein_3067	DUF3427 domain-containing protein	-
H8F26_RS15605	3187839..3188045	-	207	WP_197155549.1	type II toxin-antitoxin system HicB family antitoxin	-
H8F26_RS15610	3188101..3188457	-	357	Protein_3069	DUF3427 domain-containing protein	-
H8F26_RS15615	3188551..3188874	+	324	WP_197155551.1	nucleotidyltransferase domain-containing protein	-
H8F26_RS15620	3188896..3189264	+	369	WP_197155554.1	HEPN domain-containing protein	-
H8F26_RS15625	3189153..3189659	-	507	WP_197159371.1	hypothetical protein	-
H8F26_RS15630	3190127..3191297	+	1171	Protein_3073	IS3 family transposase	-
H8F26_RS15635	3191511..3192254	-	744	WP_197158898.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (3-79)

Antitoxin

• Protein of unknown function DUF433 (6-61)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12646.74 Da
• Isoelectric Point: 7.2039

>T170297 WP_197155545.1 NZ_CP060396:c3187057-3186713 [Synechococcus sp. CBW1006]
VILWLDAQLSPALATWIMAQWPHIQAVPLRNLGLRDAEDRDIFAHAKTAGAVVMTKDRDFLALLFKQGPPPQVIWLRVGN
SSNKALQAVLLRTLDQAIASLLEGEPWVEVRSSV

Nucleotide

• Length: 345 bp

>T170297 NZ_CP077262:c4893452-4893093 [Citrobacter pasteurii]
ATGACGAAACCACTTTACTGGGTTGGGCATGCCAGGAAAGATCTACAGGGAATGCCAGAACATGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTGGCGCAGCAGGGTAAGCAGCATTCACAGACTAAACCGTTAAAAGGATTTGGTGGGGCGGGAGTTC
TGGAAGTTGTAGAGGATTATCACGGCAACACATGGCGGGCGGTTTACACTATCCAGTTGAAAAATGCAGTTTATGTTCTG
CATGTTTTTCAGAAAAAATCTGTTTCCGGGAAGGCAACGCCGAAACCCGAAATTAACTTGATTTACCAGCGGCTTAAGGC
TGCACAGCGGCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 7824.94 Da
• Isoelectric Point: 4.2493

>AT170297 WP_197155547.1 NZ_CP060396:c3187272-3187054 [Synechococcus sp. CBW1006]
MSDSRITYNPAQCGGKPCIRGMRIRVSDVLDLYAAGLSPDQILAELPDLEPEDLQAALTYAARELDHPVLVA

Nucleotide

• Length: 219 bp

>AT170297 NZ_CP077262:c4893103-4892786 [Citrobacter pasteurii]
ATGTCACATGATATCGAAACCAGTAGCGGCAACGTTTACGCTGATTTGGGTGAGTATGACGCGGAACAGATGCAGTTGAA
GGCGCAACTGGCAATGGTGATTGGTGAGATTTTGCAATGCAAAGGGTTAACGCAGCAGCAGGCTGCACAAATGCTGGGGA
TGACGCAGCCCAAGCTTTCCAACTTATTACGCGGGCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA