Detailed information of TA system TA170296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 2757226..2757896
• Replicon: chromosome
• Accession: NZ_CP060396
• Organism: Synechococcus sp. CBW1006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H8F26_RS13490
• Protein ID: WP_197154714.1
• Coordinates: 2757226..2757645 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H8F26_RS13495
• Protein ID: WP_197154716.1
• Coordinates: 2757636..2757896 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8F26_RS13460	2753121..2754395	-	1275	WP_197158978.1	IS110 family transposase	-
H8F26_RS13465	2754761..2754928	-	168	Protein_2642	glucose-1-phosphate thymidylyltransferase	-
H8F26_RS13470	2755289..2755588	-	300	WP_197154710.1	HigA family addiction module antidote protein	-
H8F26_RS13475	2755588..2755866	-	279	WP_197159209.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H8F26_RS13480	2756007..2756177	-	171	Protein_2645	glucose-1-phosphate thymidylyltransferase	-
H8F26_RS13485	2756663..2757226	-	564	WP_197154712.1	hypothetical protein	-
H8F26_RS13490	2757226..2757645	-	420	WP_197154714.1	type II toxin-antitoxin system VapC family toxin	Toxin
H8F26_RS13495	2757636..2757896	-	261	WP_197154716.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H8F26_RS13500	2758000..2759170	-	1171	Protein_2649	IS3 family transposase	-
H8F26_RS13505	2759154..2759345	+	192	WP_197154718.1	hypothetical protein	-
H8F26_RS13510	2759817..2761432	+	1616	Protein_2651	IS3 family transposase	-
H8F26_RS13515	2761651..2762568	+	918	WP_197154720.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-59)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15331.50 Da
• Isoelectric Point: 5.7396

>T170296 WP_197154714.1 NZ_CP060396:c2757645-2757226 [Synechococcus sp. CBW1006]
MYLIDTMVLSELRLRQRDPGVVGWISNQRQEDCFVSVVSIGEIERGIARKRSSDAGFATQLAEWLDQLLRLYGDRLLPVD
VGVARRWGLLSAEIGHDSADLLIAATALERGLTVVTRNLRHFAPTGVPTMNPWSGEGGS

Nucleotide

• Length: 420 bp

>T170296 NZ_CP077262:4781999-4782286 [Citrobacter pasteurii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTTGATACAGCCATTCAGCAGCAGTTTGC
CAAAAAACTAAAGAAATGCTGTGAAAACCCGCATGTCCCCTCAGCAAAGCTCAGGGGAATAAAGGATTGCTACAAAATCA
AACTACGAACATCAGGGTTTCGTCTTGTTTATCAAGTTATTGACGACACTCTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGCAGTGAAGTCTATAACCTTGCCAGCGAAAGATTGCGCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9816.18 Da
• Isoelectric Point: 4.6151

>AT170296 WP_197154716.1 NZ_CP060396:c2757896-2757636 [Synechococcus sp. CBW1006]
MDAVWTLQDAKNRFSAVVDAAARGEPQMVTRRGKWVSVVLSAEEYERLQRLERASAPSLAELLLQMPQDDEPFERLPLTP
REFPCT

Nucleotide

• Length: 261 bp

>AT170296 NZ_CP077262:4781751-4782002 [Citrobacter pasteurii]
ATGCCGCATATTATTTTAAGCGATACCACCGCGAGCGTGAGTGAGCTGAAAAAGAACCCGATGGCGACTGTGAGCGCAGG
AAATGGGTTTCCGGTCGCAATCCTGAACCGTAACCAGCCCGCCTTTTATTGCGTGCCAGCGGAGCTTTACGAAAAAATGC
TTGATGCACTGGACGATCAGCAACTGGTTAAATTAGTCCATGAACGTAGCCAACAACCCCTGGTGGATGTGGATCTGGAC
AGCTTTTTATGA