Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 2757226..2757896 Replicon chromosome
Accession NZ_CP060396
Organism Synechococcus sp. CBW1006

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H8F26_RS13490 Protein ID WP_197154714.1
Coordinates 2757226..2757645 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H8F26_RS13495 Protein ID WP_197154716.1
Coordinates 2757636..2757896 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F26_RS13460 2753121..2754395 - 1275 WP_197158978.1 IS110 family transposase -
H8F26_RS13465 2754761..2754928 - 168 Protein_2642 glucose-1-phosphate thymidylyltransferase -
H8F26_RS13470 2755289..2755588 - 300 WP_197154710.1 HigA family addiction module antidote protein -
H8F26_RS13475 2755588..2755866 - 279 WP_197159209.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8F26_RS13480 2756007..2756177 - 171 Protein_2645 glucose-1-phosphate thymidylyltransferase -
H8F26_RS13485 2756663..2757226 - 564 WP_197154712.1 hypothetical protein -
H8F26_RS13490 2757226..2757645 - 420 WP_197154714.1 type II toxin-antitoxin system VapC family toxin Toxin
H8F26_RS13495 2757636..2757896 - 261 WP_197154716.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H8F26_RS13500 2758000..2759170 - 1171 Protein_2649 IS3 family transposase -
H8F26_RS13505 2759154..2759345 + 192 WP_197154718.1 hypothetical protein -
H8F26_RS13510 2759817..2761432 + 1616 Protein_2651 IS3 family transposase -
H8F26_RS13515 2761651..2762568 + 918 WP_197154720.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-59)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15331.50 Da        Isoelectric Point: 5.7396

>T170296 WP_197154714.1 NZ_CP060396:c2757645-2757226 [Synechococcus sp. CBW1006]
MYLIDTMVLSELRLRQRDPGVVGWISNQRQEDCFVSVVSIGEIERGIARKRSSDAGFATQLAEWLDQLLRLYGDRLLPVD
VGVARRWGLLSAEIGHDSADLLIAATALERGLTVVTRNLRHFAPTGVPTMNPWSGEGGS

Download         Length: 420 bp

>T170296 NZ_CP077262:4781999-4782286 [Citrobacter pasteurii]
ATGAGTTATACGGTAAAGTTCAGGGAAGATGCGCTGAAAGAATGGCAAAAACTTGATACAGCCATTCAGCAGCAGTTTGC
CAAAAAACTAAAGAAATGCTGTGAAAACCCGCATGTCCCCTCAGCAAAGCTCAGGGGAATAAAGGATTGCTACAAAATCA
AACTACGAACATCAGGGTTTCGTCTTGTTTATCAAGTTATTGACGACACTCTGGTCATCGCTGTCGTTGCCGTCGGTAAA
CGCGAGCGCAGTGAAGTCTATAACCTTGCCAGCGAAAGATTGCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9816.18 Da        Isoelectric Point: 4.6151

>AT170296 WP_197154716.1 NZ_CP060396:c2757896-2757636 [Synechococcus sp. CBW1006]
MDAVWTLQDAKNRFSAVVDAAARGEPQMVTRRGKWVSVVLSAEEYERLQRLERASAPSLAELLLQMPQDDEPFERLPLTP
REFPCT

Download         Length: 261 bp

>AT170296 NZ_CP077262:4781751-4782002 [Citrobacter pasteurii]
ATGCCGCATATTATTTTAAGCGATACCACCGCGAGCGTGAGTGAGCTGAAAAAGAACCCGATGGCGACTGTGAGCGCAGG
AAATGGGTTTCCGGTCGCAATCCTGAACCGTAACCAGCCCGCCTTTTATTGCGTGCCAGCGGAGCTTTACGAAAAAATGC
TTGATGCACTGGACGATCAGCAACTGGTTAAATTAGTCCATGAACGTAGCCAACAACCCCTGGTGGATGTGGATCTGGAC
AGCTTTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References