Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 2736318..2736883 Replicon chromosome
Accession NZ_CP060396
Organism Synechococcus sp. CBW1006

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H8F26_RS13325 Protein ID WP_197154680.1
Coordinates 2736318..2736662 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H8F26_RS13330 Protein ID WP_197154681.1
Coordinates 2736659..2736883 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8F26_RS13290 2732084..2733466 + 1383 WP_197154669.1 hypothetical protein -
H8F26_RS13295 2733491..2734648 + 1158 WP_197154671.1 glycosyltransferase family 9 protein -
H8F26_RS13300 2734937..2735419 + 483 WP_197154672.1 hypothetical protein -
H8F26_RS13305 2735449..2735652 + 204 WP_197159203.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
H8F26_RS13310 2735652..2735846 + 195 WP_197154678.1 PIN domain-containing protein -
H8F26_RS13315 2735991..2736143 + 153 Protein_2612 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
H8F26_RS13320 2736158..2736313 + 156 WP_197154679.1 hypothetical protein -
H8F26_RS13325 2736318..2736662 - 345 WP_197154680.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H8F26_RS13330 2736659..2736883 - 225 WP_197154681.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H8F26_RS13335 2737051..2737448 - 398 Protein_2616 VapC toxin family PIN domain ribonuclease -
H8F26_RS13340 2737417..2737674 - 258 WP_197154683.1 hypothetical protein -
H8F26_RS13345 2737592..2738047 - 456 WP_197154684.1 nucleotidyltransferase domain-containing protein -
H8F26_RS13350 2738168..2738473 - 306 WP_197154686.1 hypothetical protein -
H8F26_RS13355 2738587..2738889 - 303 WP_197154688.1 HigA family addiction module antidote protein -
H8F26_RS13360 2738889..2739161 - 273 WP_197159204.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8F26_RS13365 2739418..2740533 + 1116 Protein_2622 IS630 family transposase -
H8F26_RS13370 2740714..2741025 - 312 WP_197159205.1 type II toxin-antitoxin system PemK/MazF family toxin -
H8F26_RS13375 2741055..2741363 - 309 WP_197154690.1 ribbon-helix-helix protein, CopG family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2739436..2740371 935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-106)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12521.50 Da        Isoelectric Point: 8.5578

>T170295 WP_197154680.1 NZ_CP060396:c2736662-2736318 [Synechococcus sp. CBW1006]
VNTFETYTVVRVPFPFTERQAQKQRPAVVLSRPSFQRGCGHLLLAMITSARQSSWPLDWPLDDLQAAGLPQPCLVRFKLF
TLDERLVLGELGVLGAADRAGVSAHLGHLLPTGT

Download         Length: 345 bp

>T170295 NZ_CP077262:4000522-4000740 [Citrobacter pasteurii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGCTGTCAAACAATTGACACGCTTGAACGTGT
TATTGAGAAAAATAAATATGAATTGTCTGACAATGAACTGGCTGTATTTTACTCAGCCGCCGATCATCGTCTTGCTGAAT
TGACAATGAATAAGCTCTACGACAAGATCCCAACATCTGTTTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8150.18 Da        Isoelectric Point: 4.5535

>AT170295 WP_197154681.1 NZ_CP060396:c2736883-2736659 [Synechococcus sp. CBW1006]
MDVATLTAKGQVTVPKAVREALGLRRGDQLSWELEDGSVRVRAVTPLDLAYLHGLERGLSEWSSPADEEAFRDL

Download         Length: 225 bp

>AT170295 NZ_CP077262:4000120-4000494 [Citrobacter pasteurii]
ATGGATGAATACTCACCGAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGCAACCATGGTTGGGTAAATGACCCTACCTCCGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATTGATGAATACCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTCAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References